Genome-wide DNA methylation profiling of peripheral blood reveals an epigenetic signature associated with severe COVID-19
The global pandemic caused by the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) is a highly pathogenic RNA virus causing coronavirus disease 2019 (COVID …
(SARS-CoV-2) is a highly pathogenic RNA virus causing coronavirus disease 2019 (COVID …
A meta-analysis of immune-cell fractions at high resolution reveals novel associations with common phenotypes and health outcomes
Background Changes in cell-type composition of tissues are associated with a wide range of
diseases and environmental risk factors and may be causally implicated in disease …
diseases and environmental risk factors and may be causally implicated in disease …
Fathers' preconception smoking and offspring DNA methylation
Background Experimental studies suggest that exposures may impact respiratory health
across generations via epigenetic changes transmitted specifically through male germ cells …
across generations via epigenetic changes transmitted specifically through male germ cells …
Analysis of blood methylation quantitative trait loci in East Asians reveals ancestry-specific impacts on complex traits
Methylation quantitative trait loci (mQTLs) are essential for understanding the role of DNA
methylation changes in genetic predisposition, yet they have not been fully characterized in …
methylation changes in genetic predisposition, yet they have not been fully characterized in …
Cell-type heterogeneity: Why we should adjust for it in epigenome and biomarker studies
Most studies aiming to identify epigenetic biomarkers do so from complex tissues that are
composed of many different cell-types. By definition, these cell-types vary substantially in …
composed of many different cell-types. By definition, these cell-types vary substantially in …
EPISCORE: cell type deconvolution of bulk tissue DNA methylomes from single-cell RNA-Seq data
Cell type heterogeneity presents a challenge to the interpretation of epigenome data,
compounded by the difficulty in generating reliable single-cell DNA methylomes for large …
compounded by the difficulty in generating reliable single-cell DNA methylomes for large …
Telehealth parenting program and salivary epigenetic biomarkers in preschool children with developmental delay: NIMHD social epigenomics program
Importance Children with developmental delays are at a heightened risk of experiencing
mental health challenges, and this risk is exacerbated among racially minoritized children …
mental health challenges, and this risk is exacerbated among racially minoritized children …
[PDF][PDF] A phase II trial of guadecitabine plus atezolizumab in metastatic urothelial carcinoma progressing after initial immune checkpoint inhibitor therapy
Purpose: On the basis of preclinical evidence of epigenetic contribution to sensitivity and
resistance to immune checkpoint inhibitors (ICI), we hypothesized that guadecitabine …
resistance to immune checkpoint inhibitors (ICI), we hypothesized that guadecitabine …
Whole blood DNA methylation analysis reveals respiratory environmental traits involved in COVID-19 severity following SARS-CoV-2 infection
SARS-CoV-2 infection can cause an inflammatory syndrome (COVID-19) leading, in many
cases, to bilateral pneumonia, severe dyspnea, and in~ 5% of these, death. DNA …
cases, to bilateral pneumonia, severe dyspnea, and in~ 5% of these, death. DNA …
Self-control is associated with health-relevant disparities in buccal DNA-methylation measures of biological aging in older adults
Self-control is a personality dimension that is associated with better physical health and a
longer lifespan. Here, we examined (1) whether self-control is associated with buccal and …
longer lifespan. Here, we examined (1) whether self-control is associated with buccal and …