The TIM (T cell/transmembrane, immunoglobulin, and mucin) gene family plays a critical role
in regulating immune responses, including allergy, asthma, transplant tolerance …

Organ transplantation appears today to be the best alternative to replace the loss of vital
organs induced by various diseases. Transplants can, however, also be rejected by the …

Fetomaternal tolerance has been shown to depend both on regulatory T cells (Tregs) and
negative signals from the PD1–PDL1 costimulatory pathway. More recently, IL-17 …

Blockade of the B7: CD28 costimulatory pathway has emerged as a promising therapy to
prevent allograft rejection. However, results from the belatacept phase III clinical trial …

KIM-1 mediates epithelial phagocytosis in the injured kidney converting the proximal
epithelial cell into a phagocyte, with potentially important pathophysiological implications for …

Proteins of the transmembrane (or T cell) Ig and mucin domain (TIM) family are expressed
by multiple cell types within the immune systems of rodents and humans. Studies over the …

The proinflammatory cytokine IL-6 plays an important role in controlling T-cell differentiation,
especially the development of Th17 and regulatory T cells. To determine the function of IL-6 …

Costimulatory molecules are a heterogenous group of cell surface molecules that act to
amplify or counteract the initial activating signals provided to T cells from the T cell receptor …

Background—Interleukin-17 (IL-17), which is predominantly produced by T helper 17 cells
distinct from T helper 1 or T helper 2 cells, participates in the pathogenesis of infectious …

T cell, immunoglobulin domain and mucin domain-1 (TIM-1) is the nominant member of a
small family of related proteins that regulate immune cell activities. TIM-1 was initially …