New strategies for the transition-metal catalyzed synthesis of aliphatic amines

A Trowbridge, SM Walton, MJ Gaunt - Chemical reviews, 2020 - ACS Publications
Transition-metal catalyzed reactions that are able to construct complex aliphatic amines from
simple, readily available feedstocks have become a cornerstone of modern synthetic …

Recent updates and future perspectives in aziridine synthesis and reactivity

HJ Dequina, CL Jones, JM Schomaker - Chem, 2023 - cell.com
In this review, selected recent advances in the preparation and reactivity of aziridines using
modern synthetic approaches are highlighted, while comparing these new strategies with …

Aziridine synthesis by coupling amines and alkenes via an electrogenerated dication

DE Holst, DJ Wang, MJ Kim, IA Guzei, ZK Wickens - Nature, 2021 - nature.com
Aziridines—three-membered nitrogen-containing cyclic molecules—are important synthetic
targets. Their substantial ring strain and resultant proclivity towards ring-opening reactions …

Spatiotemporal microbial evolution on antibiotic landscapes

M Baym, TD Lieberman, ED Kelsic, R Chait, R Gross… - Science, 2016 - science.org
A key aspect of bacterial survival is the ability to evolve while migrating across spatially
varying environmental challenges. Laboratory experiments, however, often study evolution …

Synthesis and transformations of NH‐sulfoximines

M Andresini, A Tota, L Degennaro… - … –A European Journal, 2021 - Wiley Online Library
Recent years have seen a marked increase in the occurrence of sulfoximines in the
chemical sciences, often presented as valuable motifs for medicinal chemistry. This has …

New amination strategies based on nitrogen-centered radical chemistry

T **ong, Q Zhang - Chemical Society Reviews, 2016 - pubs.rsc.org
The interesting and diverse biological activities of nitrogen-containing compounds make the
construction of the C–N bond of great importance. Despite the tremendous advances that …

[HTML][HTML] The use of spirocyclic scaffolds in drug discovery

Y Zheng, CM Tice, SB Singh - Bioorganic & Medicinal Chemistry Letters, 2014 - Elsevier
Owing to their inherent three-dimensionality and structural novelty, spiro scaffolds have
been increasingly utilized in drug discovery. In this brief review, we highlight selected …

Computational studies of synthetically relevant homogeneous organometallic catalysis involving Ni, Pd, Ir, and Rh: an overview of commonly employed DFT methods …

T Sperger, IA Sanhueza, I Kalvet… - Chemical …, 2015 - ACS Publications
The field of organometallic catalysis has attracted considerable interest from both academia
and industry due to its broad applications in synthetic transformations. Pd, Ni, Rh, and Ir …

Atomically dispersed Co-N/C catalyst for divergent synthesis of nitrogen-containing compounds from alkenes

W Xue, Z Zhu, S Chen, B You… - Journal of the American …, 2023 - ACS Publications
Alkene functionalization with a single-atom catalyst (SAC) which merges homogeneous and
heterogeneous catalysis is a fascinating route to obtain high-value-added molecules …

Design and optimization of catalysts based on mechanistic insights derived from quantum chemical reaction modeling

S Ahn, M Hong, M Sundararajan, DH Ess… - Chemical …, 2019 - ACS Publications
Until recently, computational tools were mainly used to explain chemical reactions after
experimental results were obtained. With the rapid development of software and hardware …