Hypoxia-inducible factors (HIFs) are master regulators of oxygen homeostasis that match O2
supply and demand for each of the 50 trillion cells in the adult human body. Cancer cells co …

The Mediator complex controls RNA polymerase II (pol II) activity by coordinating the
assembly of pol II regulatory factors at transcription start sites and by mediating interactions …

Cell division is the basis for the propagation of life and requires accurate duplication of all
genetic information. DNA damage created during replication (replication stress) is a major …

Hypoxia is a key characteristic of the breast cancer microenvironment that promotes
expression of the transcriptional activator hypoxia-inducible factor 1 (HIF-1) and is …

Hypoxia is a persistent physiological feature of many different solid tumors and a key driver
of malignancy, and in recent years, it has been recognized as an important target for cancer …

Persistent HPV16 infection is a major cause of the global cancer burden. The viral life cycle
is dependent on the differentiation program of stratified squamous epithelium, but the …

Reduced oxygen availability (hypoxia) can act as a signalling cue in physiological
processes such as development, but also in pathological conditions such as cancer or …

Abstract Hypoxia-inducible factors (HIF)-1 and HIF-2 are master regulators of oxygen
homeostasis that regulate the expression of thousands of genes in order to match O2 supply …

The cellular microenvironment, together with intrinsic regulators, shapes stem cell identity
and differentiation capacity. Mammalian early embryos are exposed to hypoxia in vivo and …

Background: An increasing number of studies have shown that Isthmin 1 (ISM1), a secreted
protein, is important in tumorigenesis and invasion, including in colorectal cancer (CRC) …