p53 signaling in cancer progression and therapy
The p53 protein is a transcription factor known as the" guardian of the genome" because of
its critical function in preserving genomic integrity. The TP53 gene is mutated in …
its critical function in preserving genomic integrity. The TP53 gene is mutated in …
Regulating tumor suppressor genes: post-translational modifications
L Chen, S Liu, Y Tao - Signal transduction and targeted therapy, 2020 - nature.com
Tumor suppressor genes cooperate with each other in tumors. Three important tumor
suppressor proteins, retinoblastoma (Rb), p53, phosphatase, and tensin homolog deleted …
suppressor proteins, retinoblastoma (Rb), p53, phosphatase, and tensin homolog deleted …
Mutant p53 in cancer: new functions and therapeutic opportunities
PAJ Muller, KH Vousden - Cancer cell, 2014 - cell.com
Many different types of cancer show a high incidence of TP53 mutations, leading to the
expression of mutant p53 proteins. There is growing evidence that these mutant p53s have …
expression of mutant p53 proteins. There is growing evidence that these mutant p53s have …
Targeting oncogenic mutant p53 for cancer therapy
Among genetic alterations in human cancers, mutations in the tumor suppressor p53 gene
are the most common, occurring in over 50% of human cancers. The majority of p53 …
are the most common, occurring in over 50% of human cancers. The majority of p53 …
Current developments of targeting the p53 signaling pathway for cancer treatment
J Huang - Pharmacology & therapeutics, 2021 - Elsevier
Abstract p53 is one of the most well-studied tumor suppressors. It is mutated or deleted in
half of all cancers. In the other half carrying wild type p53, the p53 signaling pathway is …
half of all cancers. In the other half carrying wild type p53, the p53 signaling pathway is …
Structural and drug targeting insights on mutant p53
AS Gomes, H Ramos, A Inga, E Sousa, L Saraiva - Cancers, 2021 - mdpi.com
Simple Summary The tumor suppressor protein p53 is frequently mutated in human cancers,
and its reactivation represents an encouraging hope for precision anticancer therapy …
and its reactivation represents an encouraging hope for precision anticancer therapy …
TP53 in biology and treatment of osteosarcoma
Simple Summary Treatment of osteosarcoma, apart from chemotherapy modifications, has
not changed for approximately 30 years. Similarly, as in other tumors, mutations in the TP53 …
not changed for approximately 30 years. Similarly, as in other tumors, mutations in the TP53 …
[HTML][HTML] TP53 Mutation-Mediated Immune Evasion in Cancer: Mechanisms and Therapeutic Implications
Simple Summary p53 mutations are prevalent across a variety of human cancers and are
regarded as a major obstacle in cancer therapy. These mutations can confer resistance to …
regarded as a major obstacle in cancer therapy. These mutations can confer resistance to …
Pharmacological reactivation of p53 as a strategy to treat cancer
J Zawacka‐Pankau… - Journal of internal …, 2015 - Wiley Online Library
It has been confirmed through studies using the technique of unbiased sequencing that the
TP 53 tumour suppressor is the most frequently inactivated gene in cancer. This finding …
TP 53 tumour suppressor is the most frequently inactivated gene in cancer. This finding …
[HTML][HTML] Relevance of infection with human papillomavirus: the role of the p53 tumor suppressor protein and E6/E7 zinc finger proteins
B Ruttkay-Nedecky… - International …, 2013 - spandidos-publications.com
Human papillomaviruses (HPV) are small circular, double-stranded DNA viruses infecting
epithelial tissues. HPV types can be classified both as high-risk or low-risk. Of the more than …
epithelial tissues. HPV types can be classified both as high-risk or low-risk. Of the more than …