Redox-and non-redox-metal-induced formation of free radicals and their role in human disease
Transition metal ions are key elements of various biological processes ranging from oxygen
formation to hypoxia sensing, and therefore, their homeostasis is maintained within strict …
formation to hypoxia sensing, and therefore, their homeostasis is maintained within strict …
Nose-to-brain drug delivery: An update on clinical challenges and progress towards approval of anti-Alzheimer drugs
Abstract According to the Alzheimer Association Report (2017), Alzheimer's disease (AD) is
the 6th primary cause of death in the USA, which affects nearly 5.5 million people. In the …
the 6th primary cause of death in the USA, which affects nearly 5.5 million people. In the …
[HTML][HTML] Recent advances in the neurobiology and neuropharmacology of Alzheimer's disease
K Kumar, A Kumar, RM Keegan… - Biomedicine & …, 2018 - Elsevier
Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by
progressive deterioration of cognitive functions. The pathological hallmarks are extracellular …
progressive deterioration of cognitive functions. The pathological hallmarks are extracellular …
The multifactorial nature of Alzheimer's disease for develo** potential therapeutics
M Carmo Carreiras, E Mendes… - Current topics in …, 2013 - ingentaconnect.com
Alzheimerβs disease (AD) is a multifactorial neurodegenerative disorder with several target
proteins contributing to its aetiology. Pathological, genetic, biochemical, and modeling …
proteins contributing to its aetiology. Pathological, genetic, biochemical, and modeling …
Multitarget compounds bearing tacrine-and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease
L Ismaili, B Refouvelet, M Benchekroun, S Brogi… - Progress in …, 2017 - Elsevier
Alzheimer's disease is a multifactorial and fatal neurodegenerative disorder characterized
by decline of cholinergic function, deregulation of other neurotransmitter systems, β-amyloid …
by decline of cholinergic function, deregulation of other neurotransmitter systems, β-amyloid …
FAF-Drugs2: free ADME/tox filtering tool to assist drug discovery and chemical biology projects
D Lagorce, O Sperandio, H Galons, MA Miteva… - BMC …, 2008 - Springer
Background Drug discovery and chemical biology are exceedingly complex and demanding
enterprises. In recent years there are been increasing awareness about the importance of …
enterprises. In recent years there are been increasing awareness about the importance of …
Pivotal role of nitrogen heterocycles in Alzheimer's disease drug discovery
Alzheimer's disease (AD) is a detrimental neurodegenerative disease that progressively
worsens with time. Clinical options are limited and only provide symptomatic relief to AD …
worsens with time. Clinical options are limited and only provide symptomatic relief to AD …
Tacrine derivatives and Alzheimer's disease
To date, the pharmacotherapy of Alzheimer's disease (AD) has relied on
acetylcholinesterase (AChE) inhibitors (AChEIs) and, more recently, an N-methyl-D …
acetylcholinesterase (AChE) inhibitors (AChEIs) and, more recently, an N-methyl-D …
Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease
A combination of tacrine and tryptophan led to the development of a new family of
heterodimers as multi-target agents with potential to treat Alzheimer's disease. Based on the …
heterodimers as multi-target agents with potential to treat Alzheimer's disease. Based on the …
Natural cholinesterase inhibitors from marine organisms
Covering: Published between 1974 up to 2018 Inhibition of cholinesterases is a common
approach for the management of several disease states. Most notably, cholinesterase …
approach for the management of several disease states. Most notably, cholinesterase …