Major depressive disorder (MDD) is a common and complex mental disorder, that adversely
impacts an individual's quality of life, but its diagnosis and treatment are not accurately …

Biological embedding occurs when life experience alters biological processes to affect later
life health and well-being. Although extensive correlative data exist supporting the notion …

Epigenetic clocks are age predictors that use machine-learning models trained on DNA CpG
methylation values to predict chronological or biological age. Increases in predicted …

Redox biology is at the core of life sciences, accompanied by the close correlation of redox
processes with biological activities. Redox homeostasis is a prerequisite for human health …

Despite advances in neuroscience, limited progress has been made in develo** new and
better medications for psychiatric disorders. Available treatments in psychiatry rely on a few …

The specific regulation of inflammatory processes by steroid hormones has been actively
studied in recent years, especially by progesterone (P4) and progestins. The mechanisms of …

Chronic stress is a risk factor for numerous aging-related diseases and has been shown to
shorten lifespan in humans and other social mammals. Yet how life stress causes such a …

Altered transcriptional and epigenetic regulation of brain cell types may contribute to
cognitive changes with advanced age. Using single-nucleus multi-omic DNA methylation …

Background People with neurodegenerative disorders show diverse clinical syndromes,
genetic heterogeneity, and distinct brain pathological changes, but studies report overlap …

Responding to different dynamic levels of stress is critical for mammalian survival. Disruption
of mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) signaling is proposed to …