Low back pain is a highly prevalent, chronic, and costly medical condition predominantly
triggered by intervertebral disc degeneration (IDD). IDD is often caused by structural and …

The physiologically hypoxic intervertebral disc and cartilage rely on the hypoxia-inducible
factor (HIF) family of transcription factors to mediate cellular responses to changes in oxygen …

Intervertebral disc (IVD) degeneration (IDD) is a multifactorial pathological process
associated with low back pain (LBP). The pathogenesis is complicated, and the main …

Intervertebral disc degeneration (IVDD) is one of the leading causes of lower back pain.
Although IVDD cannot directly cause death, it can cause pain, psychological burdens, and …

Intervertebral disc degeneration (IVDD) is a main cause of lower back pain, leading to
psychological and economic burdens to patients. Physical therapy only delays pain in …

Pancreatic cancer or pancreatic ductal adenocarcinoma (PDAC) is characterized by a
profound inflammatory tumor microenvironment (TME) with high heterogeneity, metastatic …

The water flea, Daphnia magna, serves as a key model organism for investigating the
response of aquatic organisms to environmental stressors, including hypoxia. Hypoxia …

The DNA-sensing cGAS-STING pathway promotes the senescence-associated secretory
phenotype (SASP) and mediates type-I interferon inflammatory responses to foreign viral …

Low back pain is the leading cause of disability, producing a substantial socio-economic
burden on healthcare systems worldwide. Intervertebral disc (IVD) degeneration is a primary …

Nucleus pulposus (NP) apoptosis and subsequent excessive degradation of the
extracellular matrix (ECM) are key pathological characteristics of intervertebral disc …