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Regulation and metabolic functions of mTORC1 and mTORC2
Cells metabolize nutrients for biosynthetic and bioenergetic needs to fuel growth and
proliferation. The uptake of nutrients from the environment and their intracellular metabolism …
proliferation. The uptake of nutrients from the environment and their intracellular metabolism …
Natural products targeting the PI3K-Akt-mTOR signaling pathway in cancer: A novel therapeutic strategy
Abstract The phosphatidylinositol 3-kinase (PI3K)-Akt and the mammalian target of
rapamycin (mTOR) represent two vital intracellular signaling pathways, which are …
rapamycin (mTOR) represent two vital intracellular signaling pathways, which are …
[HTML][HTML] Lipid accumulation induced by APOE4 impairs microglial surveillance of neuronal-network activity
Summary Apolipoprotein E4 (APOE4) is the greatest known genetic risk factor for
develo** sporadic Alzheimer's disease. How the interaction of APOE4 microglia with …
develo** sporadic Alzheimer's disease. How the interaction of APOE4 microglia with …
PI3K/AKT/mTOR signaling in gastric cancer: Epigenetics and beyond
S Fattahi, F Amjadi-Moheb, R Tabaripour, GH Ashrafi… - Life sciences, 2020 - Elsevier
Abstract PI3K/AKT/mTOR pathway is one of the most important signaling pathways involved
in normal cellular processes. Its aberrant activation modulates autophagy, epithelial …
in normal cellular processes. Its aberrant activation modulates autophagy, epithelial …
Epidermal growth factor receptor cell proliferation signaling pathways
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is commonly
upregulated in cancers such as in non-small-cell lung cancer, metastatic colorectal cancer …
upregulated in cancers such as in non-small-cell lung cancer, metastatic colorectal cancer …
[HTML][HTML] Insulin action at a molecular level–100 years of progress
The discovery of insulin 100 years ago and its application to the treatment of human disease
in the years since have marked a major turning point in the history of medicine. The …
in the years since have marked a major turning point in the history of medicine. The …
Targeted therapy in patients with PIK3CA-related overgrowth syndrome
CLOVES syndrome (congenital lipomatous overgrowth, vascular malformations, epidermal
naevi, scoliosis/skeletal and spinal syndrome) is a genetic disorder that results from somatic …
naevi, scoliosis/skeletal and spinal syndrome) is a genetic disorder that results from somatic …
The multifaceted roles of fatty acid synthesis in cancer
Lipid metabolism, in particular the synthesis of fatty acids (FAs), is an essential cellular
process that converts nutrients into metabolic intermediates for membrane biosynthesis …
process that converts nutrients into metabolic intermediates for membrane biosynthesis …
Mechanisms of PTEN loss in cancer: It's all about diversity
V Álvarez-Garcia, Y Tawil, HM Wise… - Seminars in cancer biology, 2019 - Elsevier
PTEN is a phosphatase which metabolises PIP 3, the lipid product of PI 3-Kinase, directly
opposing the activation of the oncogenic PI3K/AKT/mTOR signalling network. Accordingly …
opposing the activation of the oncogenic PI3K/AKT/mTOR signalling network. Accordingly …
PI3Kγ is a molecular switch that controls immune suppression
Macrophages play critical, but opposite, roles in acute and chronic inflammation and
cancer,,,,. In response to pathogens or injury, inflammatory macrophages express cytokines …
cancer,,,,. In response to pathogens or injury, inflammatory macrophages express cytokines …