Importance Combined use of inhaled corticosteroids and long-acting β-agonists (LABAs) as
the controller and the quick relief therapy termedsingle maintenance and reliever therapy …

Asthma is one of the most common chronic diseases of childhood. Allergen sensitization
and high frequencies of comorbid allergic diseases are characteristic of severe asthma in …

Patients with asthma–chronic obstructive pulmonary disease overlap syndrome (ACOS)
have been largely excluded from pivotal therapeutic trials and, as a result, its treatment …

Background Studies in adults and adolescents have demonstrated that tiotropium is
efficacious as an add-on therapy to inhaled corticosteroids (ICSs) with or without other …

Asthma is a common chronic inflammatory disorder of the lower respiratory airways in
childhood. The management of asthma exacerbations and the disease control are major …

Background Long-acting beta-agonists (LABAs) have been shown to increase the risk of
asthma-related death among adults and the risk of asthma-related hospitalization among …

The pharmacological management of asthma has changed considerably in recent decades,
as it has come to be understood that it is a complex, heterogeneous disease with different …

Background Concerns remain about the safety of adding long-acting β2-agonists to inhaled
glucocorticoids for the treatment of asthma. In a postmarketing safety study mandated by the …

The pharmacological management of asthma has changed considerably in recent decades,
as it has come to be understood that it is a complex, heterogeneous disease with different …

Background Safety concerns regarding long-acting β2-agonists (LABAs) in asthma
management were initially identified in a large postmarketing trial in which the risk of death …