In the field of C–H bond functionalization chemistry, directed C–H bond activation strategies
are highly appreciated due to the high efficiency and selectivity of such reactions towards a …

Catalytic C–H bond activation, which was an elusive subject of chemical research until the
1990s, has now become a standard synthetic method for the formation of new C–C and C …

Ring structures such as pyridine, cyclopentane or their combinations are important motifs in
bioactive molecules. In contrast to previous cycloaddition reactions that necessitated a …

Organic reactions that involve the direct functionalization of non-activated C–H bonds
represent an attractive class of transformations which maximize atom-and step-economy …

Recent advances in transition metal-catalyzed C–H bond functionalization have profoundly
impacted synthetic strategy. Since organic substrates typically contain several chemically …

The research on 1, 2, 3-triazoles has been lively and ever-growing since its stimulation by
the advent of click chemistry. The attractiveness of 1H-1, 2, 3-triazoles and their derivatives …

Partially fluorinated alkanes, arenes, and alkenes can be transformed by a variety of
transition metal and lanthanide systems. Although the C–H bond is weaker than the C–F …

An isolated Csingle bondH bond in a molecule has a very low reactivity owing to the large
kinetic barrier associated to the Csingle bondH bond cleavage and the apolar nature of this …

The site-selective formation of carbonrcarbon bonds through direct functionalizations of
otherwise unreactive carbonrhydrogen bonds constitutes an economically attractive strategy …

In recent years, the pharmaceutical market has experienced a paradigm shift; as small
molecules had long been thought of as the ultimate therapeutics, the use of biologics …