Nonribosomal peptide synthetases (NRPSs) are large multienzyme machineries that
assemble numerous peptides with large structural and functional diversity. These peptides …

A systematic analysis of all naturally-occurring glycosylated bacterial secondary metabolites
reported in the scientific literature up through early 2013 is presented. This comprehensive …

The Huisgen 1, 3-dipolar cycloaddition reaction of organic azides and alkynes1, 2 has
gained considerable attention in recent years due to the introduction in 2001 of Cu (1) …

In recent years, there has been an ever‐increasing need for rapid reactions that meet the
three main criteria of an ideal synthesis: efficiency, versatility, and selectivity. Such reactions …

Dipolar cycloaddition reactions can be considered a powerful synthetic tool in the building of
heterocyclic rings, with applications in different fields. In this review we focus on the …

During the past 15 years, most large pharmaceutical companies have decreased the
screening of natural products for drug discovery in favor of synthetic compound libraries …

1.1 Aims This review updates our original review on the synthesis of glycoproteins.(1) Its
aims, therefore, are 2-fold: to highlight, first, key developments since 2002 and, second …

Cell wall biosynthesis inhibitors (CBIs) have historically been one of the most effective
classes of antibiotics. They are the most extensively used class of antibiotics and their …

Many biologically active small‐molecule natural products produced by microorganisms
derive their activities from sugar substituents. Changing the structures of these sugars can …

2.1. 1. The Copper Catalyst 2.1. 2. Auxiliary Ligands 2.2 Studies of the Mechanism of
CuAAC 2.3. The Cyclodimerization Phenomenon 2.4. One-Pot CuAAC Procedure 2.5 …