G protein–coupled receptors (GPCRs) compose one of the largest families of membrane
proteins involved in intracellular signaling. They are involved in numerous physiological and …

Chemokine receptor (CKR) signaling forms the basis of essential immune cellular functions,
and dysregulated CKR signaling underpins numerous disease processes of the immune …

G protein-coupled receptors (GPCRs) are capable of interacting to form higher order
structures such as homomers and heteromers. Heteromerisation in particular has …

Background and Purpose The C‐X‐C chemokine receptors 3 (CXCR3) and C‐X‐C
chemokine receptors 4 (CXCR4) are involved in various autoimmune diseases and cancers …

We have provided the first evidence for specific heteromerization between the α 1A-
adrenoceptor (α 1A AR) and CXC chemokine receptor 2 (CXCR2) in live cells. α 1A AR and …

Highlights•Drugs of abuse activate the neuroimmune system.•The neuroimmune system is
pivotal to the progression of addiction.•Multiple independent parallel systems are not …

Guanine nucleotide binding protein (G protein)-coupled receptors (GPCRs) function in
complexes with a range of molecules and proteins including ligands, G proteins, arrestins …

The therapies of mood and anxiety disorders are not solved, because current
antidepressants have delayed onset of therapeutic action and a significant number of …

The idea that seven transmembrane receptors (7TMRs; also designated G-protein coupled
receptors, GPCRs) might form dimers or higher order oligomeric complexes was formulated …

Opioids are considered the gold standard for the treatment of moderate to severe pain.
However, heterogeneity in analgesic efficacy, poor potency and side effects are associated …