Mitochondrial permeability transition (mPT) is a phenomenon that abruptly causes the flux of
low molecular weight solutes (molecular weight up to 1,500) across the generally …

Reactive oxygen species (ROS) have been implicated in mechanisms of heart development
and regenerative therapies such as the use of pluripotent stem cells. The roles of ROS …

The mitochondrial permeability transition pore (mPTP) is a supramolecular channel that
regulates exchange of solutes across cristae membranes, with executive roles in …

Current preclinical studies in drug development utilize high-throughput in vitro screens to
identify drug leads, followed by both in vitro and in vivo models to predict lead candidates' …

The vascular endothelium is present in all organs and blood vessels, facilitates the
exchange of nutrients and waste throughout different organ systems in the body, and sets …

The glycocalyx is a gel‐like layer covering the luminal surface of vascular endothelial cells. It
comprises of membrane‐attached proteoglycans, glycosaminoglycan chains, glycoproteins …

The ability to generate 3-dimensional models of the develo** human kidney via the
directed differentiation of pluripotent stem cells—termed kidney organoids—has been hailed …

Endothelial cells derived from human induced pluripotent stem cells (hiPSC-ECs) provide a
new opportunity for mechanistic research on vascular regeneration and drug screening …

The relevance of cellular in vitro models highly depends on their ability to mimic the
physiological environment of the respective tissue or cell niche. Static culture conditions are …

Osteoarthritis (OA) is one of the most common and widespread diseases which is highly
disabling for humans. This makes OA a chronic disease for which it is urgent to find new …