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Structures, functions, and mechanisms of filament forming enzymes: a renaissance of enzyme filamentation
Filament formation by non-cytoskeletal enzymes has been known for decades, yet only
relatively recently has its wide-spread role in enzyme regulation and biology come to be …
relatively recently has its wide-spread role in enzyme regulation and biology come to be …
Structures, mechanisms, and kinetic advantages of the SgrAI filament forming mechanism
This review documents investigations leading to the unprecedented discovery of
filamentation as a mode of enzyme regulation in the type II restriction endonuclease SgrAI …
filamentation as a mode of enzyme regulation in the type II restriction endonuclease SgrAI …
DNA binding and cleavage by the human parvovirus B19 NS1 nuclease domain
JL Sanchez, Z Romero, A Quinones, KR Torgeson… - Biochemistry, 2016 - ACS Publications
Infection with human parvovirus B19 (B19V) has been associated with a myriad of illnesses,
including erythema infectiosum (Fifth disease), hydrops fetalis, arthropathy, hepatitis, and …
including erythema infectiosum (Fifth disease), hydrops fetalis, arthropathy, hepatitis, and …
Mechanism of filamentation-induced allosteric activation of the SgrAI endonuclease
Filament formation by enzymes is increasingly recognized as an important phenomenon
with potentially unique regulatory properties and biological roles. SgrAI is an allosterically …
with potentially unique regulatory properties and biological roles. SgrAI is an allosterically …
DNA Sequence Control of Enzyme Filamentation and Activation of the SgrAI Endonuclease
Enzyme polymerization (also known as filamentation) has emerged as a new layer of
enzyme regulation. SgrAI is a sequence-dependent DNA endonuclease that forms …
enzyme regulation. SgrAI is a sequence-dependent DNA endonuclease that forms …
Structural analysis of activated SgrAI–DNA oligomers using ion mobility mass spectrometry
SgrAI is a type IIF restriction endonuclease that cuts an unusually long recognition sequence
and exhibits self-modulation of DNA cleavage activity and sequence specificity. Previous …
and exhibits self-modulation of DNA cleavage activity and sequence specificity. Previous …
The role of filamentation in activation and DNA sequence specificity of the sequence-specific endonuclease SgrAI
Filament formation by metabolic, biosynthetic, and other enzymes has recently come into
focus as a mechanism to fine-tune enzyme activity in the cell. Filamentation is key to the …
focus as a mechanism to fine-tune enzyme activity in the cell. Filamentation is key to the …
Allosteric regulation of DNA cleavage and sequence-specificity through run-on oligomerization
SgrAI is a sequence specific DNA endonuclease that functions through an unusual
enzymatic mechanism that is allosterically activated 200-to 500-fold by effector DNA, with a …
enzymatic mechanism that is allosterically activated 200-to 500-fold by effector DNA, with a …
Pretransition state and apo structures of the filament-forming enzyme SgrAI elucidate mechanisms of activation and substrate specificity
Enzyme filamentation is a widespread phenomenon that mediates enzyme regulation and
function. For the filament-forming sequence-specific DNA endonuclease SgrAI, the process …
function. For the filament-forming sequence-specific DNA endonuclease SgrAI, the process …
Zinc enhances adiponectin oligomerization to octadecamers but decreases the rate of disulfide bond formation
DB Briggs, RM Giron, K Schnittker, MV Hart, CK Park… - Biometals, 2012 - Springer
Adiponectin, a hormone secreted from adipocytes, has been shown to protect against
development of insulin resistance, ischemia–reperfusion injury, and inflammation …
development of insulin resistance, ischemia–reperfusion injury, and inflammation …