The latest studies have indicated a strong relationship between systemic insulin resistance
(IR) and higher incidence of neurodegeneration, dementia, and mild cognitive impairment …

Biologically active sphingolipids have key roles in the regulation of several fundamental
biological processes that are integral to cancer pathogenesis. Recent significant progress in …

Ceramides, composed of a sphingosine and a fatty acid, are bioactive lipid molecules
involved in many key cellular pathways (eg, apoptosis, oxidative stress and inflammation) …

Lipid peroxidation has been implicated in a variety of pathophysiological processes,
including inflammation, atherogenesis, neurodegeneration, and the ageing process …

An increasing body of evidence from animal models, human specimens and cell lines points
to reactive oxygen species as likely involved in the pathways, which convey both …

Obesity predisposes individuals to the development of insulin resistance in skeletal muscle
and the liver, and researchers have recently proposed two mechanisms by which excess …

Events—The cloning of enzymes that clear ceramide such as GCS and CDases (1, 2), the
generation of knock-out mice in acid SMase (13), and the development/discovery of specific …

Skeletal muscle shows high plasticity in response to external demand. Moreover, adult
skeletal muscle is capable of complete regeneration after injury, due to the properties of …

Obesity and dyslipidemia are risk factors for metabolic disorders including diabetes and
cardiovascular disease. Sphingolipids such as ceramide and glucosylceramides, while …

Triclosan (TCS), an extensively used antimicrobial agent, has raised considerable concern
due to its hepatocarcinogenic potential. However, previous hepatotoxicity studies primarily …