The tripartite-motif (TRIM) family represents one of the largest classes of putative single
protein RING-finger E3 ubiquitin ligases. TRIM family is involved in a variety of cellular …

Protein aggregation is a hallmark of neurodegenerative diseases. However, the mechanism
that induces pathogenic aggregation is not well understood. Recently, it has emerged that …

Background: Ferroptosis is a unique form of regulated cell death that provided a new
opportunity for cancer therapy. Ferroptosis suppressor protein 1 (FSP1) is a key regulator in …

Neurodegenerative diseases (NDs) are a diverse group of disorders characterized by the
progressive degeneration of the structure and function of the central or peripheral nervous …

Osteosarcoma is a highly aggressive malignant tumor that is common in the pediatric
population and has a high rate of disability and mortality. Recent studies have suggested …

Ubiquitination is a key mechanism for post-translational protein modification, affecting
protein localization, metabolism, degradation and various cellular physiological processes …

Breast cancer is the most prevalent malignancy in the world, and despite tremendous
progress in current treatment strategies, recurrence, metastasis and drug resistance of …

Neurodegenerative diseases and other protein-misfolding disorders represent a
longstanding biomedical challenge, and effective therapies remain largely elusive. This …

Natural Killer (NK) cells are components of innate immune surveillance against transformed
cells. NK cell immunotherapy has attracted attention as a promising strategy for cancer …

The tripartite motif (TRIM) protein family is attracting increasing interest in oncology. As a
protein family based on structure rather than function, a plethora of biological activities are …