Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Glutamate is an essential excitatory neurotransmitter in the central nervous system, playing
an indispensable role in neuronal development and memory formation. The dysregulation of …

The nucleus accumbens is a major input structure of the basal ganglia and integrates
information from cortical and limbic structures to mediate goal-directed behaviors. Chronic …

The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …

The ionotropic glutamate receptors are ligand-gated ion channels that mediate the vast
majority of excitatory neurotransmission in the brain. The cloning of cDNAs encoding …

Excitotoxicity refers to the ability of glutamate or related excitatory amino acids to mediate
the death of central neurons under certain conditions, for example, after intense exposure …

The N-methyl D-aspartate (NMDA) receptor subtype of glutamate-gated ion channels
possesses high calcium permeability and unique voltage-dependent sensitivity to …

Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that mediate
chemical communication between neurons at synapses. A variant iGluR subfamily, the …

The glutamate receptors mediate excitatory neurotransmission in the brain and are
important in memory acquisition, learning, and some neurodegenerative disorders. This …

Estradiol is the most potent and ubiquitous member of a class of steroid hormones called
estrogens. Fetuses and newborns are exposed to estradiol derived from their mother, their …