Digital twins employ mathematical and computational models to virtually represent a
physical object (eg, planes and human organs), predict the behavior of the object, and …

Simple Summary Tumor angiogenesis is one of the most critical steps in the progression of
cancer. Owing to its fundamental role in tumor growth and metastasis, tumor angiogenesis is …

Computational models are not just appealing because they can simulate and predict the
development of biological phenomena across multiple spatial and temporal scales, but also …

Abstract New nicotinamide derivatives 6, 7, 10, and 11 were designed and synthesised
based on the essential features of the VEGFR-2 inhibitors. Compound 10 revealed the …

One of the leading causes of cancer-related deaths worldwide is colorectal cancer (CRC).
Extracellular ATP (e-ATP) and purinergic receptors (P2R) play a central role in CRC …

Simple Summary The recruitment of new vasculature via angiogenesis is a critical
component of tumor development, which fundamentally influences tumor growth and …

Angiogenesis is a highly regulated multiscale process that involves a plethora of cells, their
cellular signal transduction, activation, proliferation, differentiation, as well as their …

Hybrid multiscale agent-based models (ABMs) are unique in their ability to simulate
individual cell interactions and microenvironmental dynamics. Unfortunately, the high …

Context: Computational modeling involves the use of computer simulations and models to
study and understand real-world phenomena. Its application is particularly relevant in the …

Prostate cancer can be lethal in advanced stages, for which chemotherapy may become the
only viable therapeutic option. While there is no clear clinical management strategy fitting all …