Lysosomes and lysosomal hydrolases, including the cathepsins, have been shown to
change their properties with aging brain a long time ago, although their function was not …

Cathepsin B (CTSB) is a powerful lysosomal protease. This review evaluated CTSB gene
knockout (KO) outcomes for amelioration of brain dysfunctions in neurologic diseases and …

Iron, cobalt and nitrogen co-doped carbon dots (FeCo/N-CDs) were fabricated firstly by a
one pot hydrothermal method in this study. As well as exhibiting peroxidase-like activity, the …

The last years have seen a steady increase in our understanding of legumain biology that is
driven from two largely uncoupled research arenas, the mammalian and the plant legumain …

The last decade has witnessed enormous progress of protein inhibitors of cysteine
proteinases concerning their structures, functions and evolutionary relationships. Although …

The structural organization of the gene for the human cysteine-proteinase inhibitor cystatin C
was studied. Restriction-endonuclease digests of human genomic DNA hybridized with …

Since 1985, cystatin C has been suggested to be a marker of the renal function. Cystatin C is
a proteinase inhibitor with a low molecular weight (M r= 13359). It is produced at a constant …

Low molecular-mass plasma proteins play a key role in health and disease. Cystatin C is an
endogenous cysteine proteinase inhibitor belonging to the type 2 cystatin superfamily. The …

Publisher Summary This chapter focuses on the most well characterized inhibitors—cystatin
C—and provide some information on its structure, biochemical properties, its role in normal …

The pathogenesis of atherosclerosis and abdominal aortic aneurysm involves breakdown of
the elastic laminae. Elastolytic cysteine proteases, including cathepsins S and K, are …