Triazole demonstrates distinctive physicochemical properties, characterized by weak
basicity, various dipole moments, and significant dual hydrogen bond acceptor and donor …

With the increasing risk of invasive and life threating fungal infections, there is now a great
concern regarding the lower discovery rate of antifungal drugs in comparison to …

Triazole compounds containing three nitrogen atoms in the five-membered aromatic azole
ring are readily able to bind with a variety of enzymes and receptors in biological system via …

The triazole nucleus is one of the most important and well known heterocycles which is a
common and integral feature of a variety of natural products and medicinal agents. Triazole …

Advances in the development of newly developed fluorinated drugs, approved or in clinical
trials, as organized by biological targets/disease states, are reviewed. In a few cases …

Cytochrome P450 monooxygenases of fungi are involved in many essential cellular
processes and play diverse roles. The enzymes catalyze the conversion of hydrophobic …

Within the last few years a considerable amount of evaluative studies has been published
that investigate the performance of 3D virtual screening approaches. Thereby, in particular …

Azole derivatives were synthesized by iron-catalyzed oxidative reactions of azoles and
ethers in good to excellent yields. A wide variety of azoles and ethers were selectively …

Computer-aided drug design plays a vital role in drug discovery and development and has
become an indispensable tool in the pharmaceutical industry. Computational medicinal …

A series of α-triazolyl chalcones were efficiently synthesized. Most of the prepared
compounds showed effective antibacterial and antifungal activities. Noticeably, α-triazolyl …