Post-zygotic variation refers to genetic changes that arise in the soma of an individual and
that are not usually inherited by the next generation. Although there is a paucity of research …

Transposable elements (TEs) are genomic parasites found in nearly all eukaryotes,
including humans. This evolutionary success of TEs is due to their replicative activity …

Transposable elements (TEs) have been extensively studied for decades. In recent years,
the introduction of whole-genome and whole-transcriptome approaches, as well as single …

Retrotransposons are transposable elements (TEs) capable of “jum**” in germ, embryonic
and tumor cells and, as is now clearly established, in the neuronal lineage. Mosaic TE …

Long interspersed nuclear elements-1 (LINE-1 or L1) are mobile DNA sequences that are
capable of duplication and insertion (retrotransposition) within the genome. Recently …

Over the past decade, major discoveries in retrotransposon biology have depicted the
neural genome as a dynamic structure during life. In particular, the retrotransposon LINE-1 …

Alu elements are a highly successful family of primate-specific retrotransposons that have
fundamentally shaped primate evolution, including the evolution of our own species. Alu s …

One of the most curious findings emerged from genome-wide studies over the last decade
was that genetic mosaicism is a dominant feature of human ageing genomes. The clonal …

Many neurodegenerative diseases are associated with chronic inflammation in the brain
and periphery giving rise to a continuous imbalance of immune processes. Next to …

Transposable elements make up a much larger portion of the genome than protein-coding
genes, yet we know relatively little about their function in the human genome. However, we …