[HTML][HTML] Oral delivery of proteins and peptides: Challenges, status quo and future perspectives

Q Zhu, Z Chen, PK Paul, Y Lu, W Wu, J Qi - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Proteins and peptides (PPs) have gradually become more attractive therapeutic molecules
than small molecular drugs due to their high selectivity and efficacy, but fewer side effects …

Subcritical water for the extraction and hydrolysis of protein and other fractions in biorefineries from agro-food wastes and algae: A review

M Álvarez-Viñas, P Rodríguez-Seoane… - Food and Bioprocess …, 2021 - Springer
Low-cost plant and algal biomass are increasingly demanded as a source of proteins, and
also, peptides and amino acids are gaining interest for their biological and functional …

β-Casomorphin: A complete health perspective

M Thiruvengadam, B Venkidasamy, P Thirupathi… - Food Chemistry, 2021 - Elsevier
Abstract β-Casomorphin-7 (BCM-7) is a heptapeptide dietary molecule derived from the
digestion of the β-casein of dairy and dairy products. In this review, we have covered the …

[HTML][HTML] Thrombosis and COVID-19: The Potential role of nutrition

A Tsoupras, R Lordan, I Zabetakis - Frontiers in Nutrition, 2020 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for the
coronavirus disease (COVID-19), is a contagion that has rapidly spread around the globe …

The Synergistic Effect of Ginkgo biloba Extract 50 and Aspirin Against Platelet Aggregation

J Ke, MT Li, YJ Huo, YQ Cheng, SF Guo… - Drug Design …, 2021 - Taylor & Francis
Purpose We aimed to investigate potential synergistic antiplatelet effects of Ginkgo biloba
extract (GBE50) in combination with aspirin using in vitro models. Methods Arachidonic acid …

[PDF][PDF] Oral delivery of peptide and protein therapeutics: challenges and strategies.

P Vishvakarma, R Kumari, SM Vanmathi… - Journal of …, 2023 - researchgate.net
This review explores the challenges and strategies in oral delivery of peptide and protein
therapeutics. Physiological barriers such as the gastrointestinal tract, enzymatic …

A TNF-α blocking peptide that reduces NF-κB and MAPK activity for attenuating inflammation

Y Wang, R Ye, L Fan, X Zhao, L Li, H Zheng… - Bioorganic & Medicinal …, 2023 - Elsevier
Overexpression of tumor necrosis factor-α (TNF-α) is implicated in many inflammatory
diseases, including septic shock, hepatitis, asthma, insulin resistance and autoimmune …

The Current and Promising Oral Delivery Methods for Protein-and Peptide-Based Drugs

M Nicze, M Borówka, A Dec, A Niemiec… - International Journal of …, 2024 - mdpi.com
Drugs based on peptides and proteins (PPs) have been widely used in medicine, beginning
with insulin therapy in patients with diabetes mellitus over a century ago. Although the oral …

Hydroxyls on the B ring and gallic acyl are essential for catechins to restrain ADP-induced thrombosis

Y Pan, X Feng, S Zhou, S Yang, P Qiu, S Gong… - Food & Function, 2023 - pubs.rsc.org
Platelet hyperactivation could lead to various cardiovascular and cerebrovascular diseases,
while epidemiological analyses have found that long-term tea drinking could prevent and …

Unveiling the Potent Fibrino(geno)lytic, Anticoagulant, and Antithrombotic Effects of Papain, a Cysteine Protease from Carica papaya Latex Using κ-Carrageenan Rat …

HR Yang, MN Zahan, Y Yoon, K Kim… - International Journal of …, 2023 - mdpi.com
While fibrinolytic enzymes and thrombolytic agents offer assistance in treating
cardiovascular diseases, the existing options are associated with a range of adverse effects …