With the rapid development of biotechnology, the number of biological sequences has
grown exponentially. The continuous expansion of biological sequence data promotes the …

The application of single-cell RNA sequencing (scRNA-seq) in biomedical research has
advanced our understanding of the pathogenesis of disease and provided valuable insights …

Single-cell transcriptomics (scRNA-seq) has greatly advanced our ability to characterize
cellular heterogeneity. However, scRNA-seq requires lysing cells, which impedes further …

Measurement of the location of molecules in tissues is essential for understanding tissue
formation and function. Previously, we developed Slide-seq, a technology that enables …

Multi-omic single-cell datasets, in which multiple molecular modalities are profiled within the
same cell, offer an opportunity to understand the temporal relationship between epigenome …

Trajectory inference approaches analyze genome-wide omics data from thousands of single
cells and computationally infer the order of these cells along developmental trajectories …

Computational single-cell RNA-seq (scRNA-seq) methods have been successfully applied
to experiments representing a single condition, technology, or species to discover and …

Single-cell trajectories can unveil how gene regulation governs cell fate decisions. However,
learning the structure of complex trajectories with multiple branches remains a challenging …

Single cell RNA-sequencing (scRNA-seq) technology has undergone rapid development in
recent years, leading to an explosion in the number of tailored data analysis methods …

RNA sequencing (RNA-seq) is a genomic approach for the detection and quantitative
analysis of messenger RNA molecules in a biological sample and is useful for studying …