Epidemiology, staging, and management of multiple myeloma

SA Padala, A Barsouk, A Barsouk, P Rawla, A Vakiti… - Medical …, 2021 - mdpi.com
Multiple myeloma (MM) is a plasma cell disorder that is on the rise throughout the world,
especially in the US, Australia, and Western Europe. In the US, MM accounts for almost 2 …

Prognostic and predictive biomarker developments in multiple myeloma

CT Wallington-Beddoe, RL Mynott - Journal of hematology & oncology, 2021 - Springer
New approaches to stratify multiple myeloma patients based on prognosis and therapeutic
decision-making, or prediction, are needed since patients are currently managed in a similar …

Multiple myeloma: 2022 update on diagnosis, risk stratification, and management

SV Rajkumar - American journal of hematology, 2022 - Wiley Online Library
Abstract Disease Overview Multiple myeloma accounts for approximately 10% of
hematologic malignancies. Diagnosis The diagnosis requires≥ 10% clonal bone marrow …

Second revision of the International Staging System (R2-ISS) for overall survival in multiple myeloma: a European Myeloma Network (EMN) report within the …

M D'agostino, DA Cairns, JJ Lahuerta… - Journal of clinical …, 2022 - ascopubs.org
PURPOSE Patients with newly diagnosed multiple myeloma (NDMM) show heterogeneous
outcomes, and approximately 60% of them are at intermediate-risk according to the Revised …

Carfilzomib with cyclophosphamide and dexamethasone or lenalidomide and dexamethasone plus autologous transplantation or carfilzomib plus lenalidomide and …

F Gay, P Musto, D Rota-Scalabrini, L Bertamini… - The Lancet …, 2021 - thelancet.com
Background Bortezomib-based induction followed by high-dose melphalan (200 mg/m 2)
and autologous stem-cell transplantation (MEL200-ASCT) and maintenance treatment with …

Comprehensive molecular profiling of multiple myeloma identifies refined copy number and expression subtypes

S Skerget, D Penaherrera, A Chari, S Jagannath… - Nature Genetics, 2024 - nature.com
Multiple myeloma is a treatable, but currently incurable, hematological malignancy of
plasma cells characterized by diverse and complex tumor genetics for which precision …

A high-risk, Double-Hit, group of newly diagnosed myeloma identified by genomic analysis

BA Walker, K Mavrommatis, CP Wardell, TC Ashby… - Leukemia, 2019 - nature.com
Patients with newly diagnosed multiple myeloma (NDMM) with high-risk disease are in need
of new treatment strategies to improve the outcomes. Multiple clinical, cytogenetic, or gene …

Bortezomib with lenalidomide and dexamethasone versus lenalidomide and dexamethasone alone in patients with newly diagnosed myeloma without intent for …

BGM Durie, A Hoering, MH Abidi, SV Rajkumar… - The Lancet, 2017 - thelancet.com
Background Lenalidomide plus dexamethasone is a reference treatment for patients with
newly diagnosed myeloma. The combination of the proteasome inhibitor bortezomib with …

Minimal residual disease negativity using deep sequencing is a major prognostic factor in multiple myeloma

A Perrot, V Lauwers-Cances, J Corre… - Blood, The Journal …, 2018 - ashpublications.org
The introduction of novel agents has led to major improvements in clinical outcomes for
patients with multiple myeloma. To shorten evaluation times for new treatments, health …

Multiple myeloma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

P Moreau, J San Miguel, P Sonneveld… - Annals of …, 2017 - annalsofoncology.org
Multiple myeloma (MM) accounts for 1% of all cancers and $10% of all haematological
malignancies. The incidence in Europe is 4.5–6.0/100 000/year with a median age at …