Apoptosis is a form of programmed cell death that is mediated by intrinsic and extrinsic
pathways. Dysregulation of and resistance to cell death are hallmarks of cancer. For over …

Simple Summary Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)
plays an important role in apoptosis and tumor immunosurveillance. Because TRAIL …

Background Pediatric diffuse midline gliomas (DMGs) are incurable childhood cancers. The
imipridone ONC201 has shown early clinical efficacy in a subset of DMGs. However, the …

Chemo-activation of mitochondrial ClpP exhibits promising anticancer properties. However,
we are currently unaware of any studies using selective and potent ClpP activators in lung …

Abstract Dopamine (DA, 3-hydroxytyramine) is a member of the catecholamine family and is
classically characterized according to its role in the central nervous system as a …

Mitochondria, the main provider of energy in eukaryotic cells, contains more than 1000
different proteins and is closely related to the development of cells. However, damaged …

The integrated stress response (ISR) triggered in response to various cellular stress enables
mammalian cells to effectively cope with diverse stressful conditions while maintaining their …

The oncogene MYC is dysregulated in a host of human cancers, and as an important point
of convergence in multitudinous oncogenic signaling pathways, it plays a crucial role in …

The discovery of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) along with
its potent and selective antitumor effects initiated a decades-long search for therapeutic …

The mitochondrial caseinolytic protease P (ClpP) is a target candidate for treating leukemia;
however, the effects of ClpP modulation on solid tumors have not been adequately explored …