Macropinocytosis is defined as an actin-dependent but coat-and dynamin-independent
endocytic uptake process, which generates large intracellular vesicles (macropinosomes) …

Macropinocytosis is increasingly recognized for its versatile adaptations and functions as a
highly conserved, ubiquitous pathway for the bulk uptake of fluid, particulate cargo, and …

Hepatocellular carcinoma (HCC) invariably exhibits inadequate O2 (hypoxia) and nutrient
supply. Hypoxia-inducible factor (HIF) mediates cascades of molecular events that enable …

Endocytosis mechanisms are one of the methods that cells use to interact with their
environments. Endocytosis mechanisms vary from the clathrin-mediated endocytosis to the …

Circular RNAs (circRNAs) have emerged as crucial regulators in physiology and human
diseases. However, evolutionarily conserved circRNAs with potent functions in cancers are …

Nutrient supply and demand delineate cell behavior in health and disease. Mammalian cells
have developed multiple strategies to secure the necessary nutrients that fuel their …

Over the last two decades, the rapidly expanding field of tumor metabolism has enhanced
our knowledge of the impact of nutrient availability on metabolic reprogramming in cancer …

Triple-negative breast cancer (TNBC) metabolism and cell growth uniquely rely on
glutamine uptake by the transporter ASCT2. Despite previous data reporting cell growth …

Macropinocytosis is an effective strategy to mitigate nutrient starvation. It can fuel cancer cell
growth in nutrient‐limited conditions. However, whether and how macropinocytosis …

Macropinocytosis is a form of endocytosis which provides an effective way for non-selective
uptakes of extracellular proteins, liquids, and particles. The endocytic process is initiated by …