The issue of treating sickle cell disease with drugs that increase hemoglobin oxygen affinity
has come to the fore with the US Food and Drug Administration approval in 2019 of …

Sickle cell disease (SCD) is a monogenic disorder characterized by recurrent episodes of
severe bone pain, multi-organ failure, and early mortality. Although medical progress over …

Microbial synthesis of valuable hemoproteins has become a popular research topic, and
Pichia pastoris is a versatile platform for the industrial production of recombinant proteins …

Introduction Sickle cell disease and β thalassemia are the principal β hemoglobinopathies.
The complex pathophysiology of sickle cell disease is initiated by sickle hemoglobin …

Stem cell transplantation and genetic therapies offer potential cures for patients with sickle
cell disease (SCD), but these options require advanced medical facilities and are expensive …

Characterization of blood flow rheology in hematological disorders is critical for
understanding disease pathophysiology. Existing methods to measure blood rheological …

The pathology of sickle cell disease is caused by polymerization of the abnormal
hemoglobin S upon deoxygenation in the tissues to form fibers in red cells, causing them to …

We previously reported initial clinical results of post-transcriptional gene silencing of
BCL11A expression (NCT 03282656) reversing the fetal to adult hemoglobin switch. A goal …

Sickle cell disease (SCD) is an inherited blood disorder that affects millions of people
worldwide, especially in low-resource regions of the world, where a rapid and affordable test …

FIGURE 1 Pathophysiology and HbS polymerization. HbS polymerization (left) initiates the
pathology of disease that has two interrelated limbs. These are hemolytic anemia-a varying …