Kisspeptins and reproduction: physiological roles and regulatory mechanisms

L Pinilla, E Aguilar, C Dieguez, RP Millar… - Physiological …, 2012 - journals.physiology.org
Procreation is essential for survival of species. Not surprisingly, complex neuronal networks
have evolved to mediate the diverse internal and external environmental inputs that regulate …

The emerging therapeutic potential of kisspeptin and neurokinin B

B Patel, K Koysombat, EG Mills, J Tsoutsouki… - Endocrine …, 2024 - academic.oup.com
Kisspeptin (KP) and neurokinin B (NKB) are neuropeptides that govern the reproductive
endocrine axis through regulating hypothalamic gonadotropin-releasing hormone (GnRH) …

Metabolic control of puberty: roles of leptin and kisspeptins

MA Sanchez-Garrido, M Tena-Sempere - Hormones and behavior, 2013 - Elsevier
This article is part of a Special Issue “Puberty and Adolescence”. Reproduction is an energy-
demanding function. Accordingly, puberty is metabolically gated, as a means to prevent …

Kisspeptin cells in the ewe brain respond to leptin and communicate with neuropeptide Y and proopiomelanocortin cells

K Backholer, JT Smith, A Rao, A Pereira, J Iqbal… - …, 2010 - academic.oup.com
Kisspeptin stimulates reproduction, and kisspeptin cells in the arcuate nucleus (ARC)
express Ob-Rb in the mouse. Herein we report studies in ewes to determine whether …

Impaired kisspeptin signaling decreases metabolism and promotes glucose intolerance and obesity

KP Tolson, C Garcia, S Yen, S Simonds… - The Journal of clinical …, 2014 - jci.org
The neuropeptide kisspeptin regulates reproduction by stimulating gonadotropin-releasing
hormone (GnRH) neurons via the kisspeptin receptor KISS1R. In addition to GnRH neurons …

[PDF][PDF] Serum levels of spexin and kisspeptin negatively correlate with obesity and insulin resistance in women

PA Kołodziejski, E Pruszyńska-Oszmałek… - Physiological …, 2018 - biomed.cas.cz
Spexin (SPX) and kisspeptin (KISS) are novel peptides relevant in the context of regulation
of metabolism, food intake, puberty and reproduction. Here, we studied changes of serum …

Kisspeptin directly excites anorexigenic proopiomelanocortin neurons but inhibits orexigenic neuropeptide Y cells by an indirect synaptic mechanism

LY Fu, AN van den Pol - Journal of Neuroscience, 2010 - jneurosci.org
The neuropeptide kisspeptin is necessary for reproduction, fertility, and puberty. Here, we
show strong kisspeptin innervation of hypothalamic anorexigenic proopiomelanocortin …

Evidence for two distinct KiSS genes in non-placental vertebrates that encode kisspeptins with different gonadotropin-releasing activities in fish and mammals

A Felip, S Zanuy, R Pineda, L Pinilla, M Carrillo… - Molecular and cellular …, 2009 - Elsevier
Kisspeptins, the products of KiSS-1 gene, have recently emerged as fundamental regulators
of reproductive function in different mammalian and, presumably, non-mammalian species …

The impact of adipose tissue-derived factors on the hypothalamic-pituitary-gonadal (HPG) axis

C Tsatsanis, E Dermitzaki, P Avgoustinaki, N Malliaraki… - Hormones, 2015 - Springer
Adipose tissue produces factors, including adipokines, cytokines and chemokines which,
when released, systemically exert endocrine effects on multiple tissues thereby affecting …

The effects of kisspeptin on β‐cell function, serum metabolites and appetite in humans

C Izzi‐Engbeaya, AN Comninos… - Diabetes, Obesity …, 2018 - Wiley Online Library
Aims To investigate the effect of kisspeptin on glucose‐stimulated insulin secretion and
appetite in humans. Materials and methods In 15 healthy men (age: 25.2±1.1 years; BMI …