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Kisspeptins and reproduction: physiological roles and regulatory mechanisms
L Pinilla, E Aguilar, C Dieguez, RP Millar… - Physiological …, 2012 - journals.physiology.org
Procreation is essential for survival of species. Not surprisingly, complex neuronal networks
have evolved to mediate the diverse internal and external environmental inputs that regulate …
have evolved to mediate the diverse internal and external environmental inputs that regulate …
The emerging therapeutic potential of kisspeptin and neurokinin B
B Patel, K Koysombat, EG Mills, J Tsoutsouki… - Endocrine …, 2024 - academic.oup.com
Kisspeptin (KP) and neurokinin B (NKB) are neuropeptides that govern the reproductive
endocrine axis through regulating hypothalamic gonadotropin-releasing hormone (GnRH) …
endocrine axis through regulating hypothalamic gonadotropin-releasing hormone (GnRH) …
Metabolic control of puberty: roles of leptin and kisspeptins
MA Sanchez-Garrido, M Tena-Sempere - Hormones and behavior, 2013 - Elsevier
This article is part of a Special Issue “Puberty and Adolescence”. Reproduction is an energy-
demanding function. Accordingly, puberty is metabolically gated, as a means to prevent …
demanding function. Accordingly, puberty is metabolically gated, as a means to prevent …
Kisspeptin cells in the ewe brain respond to leptin and communicate with neuropeptide Y and proopiomelanocortin cells
Kisspeptin stimulates reproduction, and kisspeptin cells in the arcuate nucleus (ARC)
express Ob-Rb in the mouse. Herein we report studies in ewes to determine whether …
express Ob-Rb in the mouse. Herein we report studies in ewes to determine whether …
Impaired kisspeptin signaling decreases metabolism and promotes glucose intolerance and obesity
The neuropeptide kisspeptin regulates reproduction by stimulating gonadotropin-releasing
hormone (GnRH) neurons via the kisspeptin receptor KISS1R. In addition to GnRH neurons …
hormone (GnRH) neurons via the kisspeptin receptor KISS1R. In addition to GnRH neurons …
[PDF][PDF] Serum levels of spexin and kisspeptin negatively correlate with obesity and insulin resistance in women
Spexin (SPX) and kisspeptin (KISS) are novel peptides relevant in the context of regulation
of metabolism, food intake, puberty and reproduction. Here, we studied changes of serum …
of metabolism, food intake, puberty and reproduction. Here, we studied changes of serum …
Kisspeptin directly excites anorexigenic proopiomelanocortin neurons but inhibits orexigenic neuropeptide Y cells by an indirect synaptic mechanism
LY Fu, AN van den Pol - Journal of Neuroscience, 2010 - jneurosci.org
The neuropeptide kisspeptin is necessary for reproduction, fertility, and puberty. Here, we
show strong kisspeptin innervation of hypothalamic anorexigenic proopiomelanocortin …
show strong kisspeptin innervation of hypothalamic anorexigenic proopiomelanocortin …
Evidence for two distinct KiSS genes in non-placental vertebrates that encode kisspeptins with different gonadotropin-releasing activities in fish and mammals
Kisspeptins, the products of KiSS-1 gene, have recently emerged as fundamental regulators
of reproductive function in different mammalian and, presumably, non-mammalian species …
of reproductive function in different mammalian and, presumably, non-mammalian species …
The impact of adipose tissue-derived factors on the hypothalamic-pituitary-gonadal (HPG) axis
C Tsatsanis, E Dermitzaki, P Avgoustinaki, N Malliaraki… - Hormones, 2015 - Springer
Adipose tissue produces factors, including adipokines, cytokines and chemokines which,
when released, systemically exert endocrine effects on multiple tissues thereby affecting …
when released, systemically exert endocrine effects on multiple tissues thereby affecting …
The effects of kisspeptin on β‐cell function, serum metabolites and appetite in humans
C Izzi‐Engbeaya, AN Comninos… - Diabetes, Obesity …, 2018 - Wiley Online Library
Aims To investigate the effect of kisspeptin on glucose‐stimulated insulin secretion and
appetite in humans. Materials and methods In 15 healthy men (age: 25.2±1.1 years; BMI …
appetite in humans. Materials and methods In 15 healthy men (age: 25.2±1.1 years; BMI …