The RUNX family of transcription factors, including RUNX1, RUNX2, and RUNX3, are key
regulators of development and can function as either tumor suppressors or oncogenes in …

Core binding factor acute myeloid leukemia (CBF AML), defined by t (8; 21) or inv (16), is a
subset of favorable risk AML. Despite its association with a high complete remission rate …

Transcription factors (TFs) play critical roles in hematopoiesis, and their aberrant expression
can lead to various types of leukemia. The t (8; 21) leukemogenic fusion protein AML1–ETO …

Blood comprises a wide array of specialized cells, all of which share the same genetic
information and ultimately derive from the same precursor, the hematopoietic stem cell …

Abstract Background t (8; 21)(q22; q22) is one of the most frequent chromosomal
abnormalities in acute myeloid leukemia (AML), leading to the generation of the fusion …

Introduction Leukemia is typically categorized into myeloid leukemia and lymphoblastic
leukemia based on the origins of leukemic cells. Myeloid leukemia is a group of clonal …

A major challenge in the stem cell biology field is the ability to produce fully functional cells
from induced pluripotent stem cells (iPSCs) that are a valuable resource for cell therapy …

Leukemia is a heterogeneous group of life‐threatening malignant disorders of the
hematopoietic system. Immunotherapy, radiotherapy, stem cell transplantation, targeted …

In myeloid neoplasms, both fusion genes and gene mutations are well‐established events
identifying clinicopathological entities. In this study, we present a thus far undescribed t (X; …

Although the prevalence of leukemia is increasing, the agents responsible for this increase
are not definitely known. While ionizing radiation (IR) was classified as a group one …