Variation, mosaicism and degeneracy in the hominin foot
The fossil record is scarce and incomplete by nature. Animals and ecological processes
devour soft tissue and important bony details over time and, when the dust settles, we are …
devour soft tissue and important bony details over time and, when the dust settles, we are …
The optimality of the standard genetic code assessed by an eight-objective evolutionary algorithm
M Wnętrzak, P Błażej, D Mackiewicz… - BMC Evolutionary …, 2018 - Springer
Background The standard genetic code (SGC) is a unique set of rules which assign amino
acids to codons. Similar amino acids tend to have similar codons indicating that the code …
acids to codons. Similar amino acids tend to have similar codons indicating that the code …
Optimization of the standard genetic code in terms of two mutation types: point mutations and frameshifts
The distinct structure and universality of the standard genetic code (SGC) have fascinated
the scientists ever since the first amino acid assignments were discovered. There are …
the scientists ever since the first amino acid assignments were discovered. There are …
Many alternative and theoretical genetic codes are more robust to amino acid replacements than the standard genetic code
We evaluated the differences between the standard genetic code (SGC) and its known
alternative variants in terms of the consequences of amino acids replacements. Furthermore …
alternative variants in terms of the consequences of amino acids replacements. Furthermore …
[PDF][PDF] The Impact of the Transversion/Transition Ratio on the Optimal Genetic Code Graph Partition.
The standard genetic code (SGC) is a system of rules ascribing 20 amino acids and stop
translation signal to 64 codons, ie triplets of nucleotides. It was proposed that the structure of …
translation signal to 64 codons, ie triplets of nucleotides. It was proposed that the structure of …
Optimization of amino acid replacement costs by mutational pressure in bacterial genomes
P Błażej, D Mackiewicz, M Grabińska, M Wnętrzak… - Scientific reports, 2017 - nature.com
Mutations are considered a spontaneous and random process, which is important
component of evolution because it generates genetic variation. On the other hand, mutations …
component of evolution because it generates genetic variation. On the other hand, mutations …
The influence of different types of translational inaccuracies on the genetic code structure
Background The standard genetic code is a recipe for assigning unambiguously 21 labels,
ie amino acids and stop translation signal, to 64 codons. However, at early stages of the …
ie amino acids and stop translation signal, to 64 codons. However, at early stages of the …
Optimization of mutation pressure in relation to properties of protein-coding sequences in bacterial genomes
Most mutations are deleterious and require energetically costly repairs. Therefore, it seems
that any minimization of mutation rate is beneficial. On the other hand, mutations generate …
that any minimization of mutation rate is beneficial. On the other hand, mutations generate …
The structure of the genetic code as an optimal graph clustering problem
The standard genetic code (SGC) is the set of rules by which genetic information is
translated into proteins, from codons, ie triplets of nucleotides, to amino acids. The questions …
translated into proteins, from codons, ie triplets of nucleotides, to amino acids. The questions …
Optimisation of asymmetric mutational pressure and selection pressure around the universal genetic code
One of hypotheses explaining the origin of the genetic code assumes that its evolution has
minimised the deleterious effects of mutations in coded proteins. To estimate the level of …
minimised the deleterious effects of mutations in coded proteins. To estimate the level of …