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Novel therapeutic targets in depression: minocycline as a candidate treatment
JK Soczynska, RB Mansur, E Brietzke… - Behavioural brain …, 2012 - Elsevier
Mood disorders are marked by high rates of non-recovery, recurrence, and chronicity, which
are insufficiently addressed by current therapies. Several patho-etiological models have …
are insufficiently addressed by current therapies. Several patho-etiological models have …
Dysregulated neuronal–microglial cross-talk during aging, stress and inflammation
HA Jurgens, RW Johnson - Experimental neurology, 2012 - Elsevier
Communication between neurons and microglia is essential for maintaining homeostasis in
the central nervous system (CNS) during both physiological and inflammatory conditions …
the central nervous system (CNS) during both physiological and inflammatory conditions …
Microglial phagocytosis of living photoreceptors contributes to inherited retinal degeneration
L Zhao, MK Zabel, X Wang, W Ma, P Shah… - EMBO molecular …, 2015 - embopress.org
Retinitis pigmentosa, caused predominantly by mutations in photoreceptor genes, currently
lacks comprehensive treatment. We discover that retinal microglia contribute non‐cell …
lacks comprehensive treatment. We discover that retinal microglia contribute non‐cell …
[HTML][HTML] Gut microbiota indole-3-propionic acid mediates neuroprotective effect of probiotic consumption in healthy elderly: A randomized, double-blind, placebo …
Background & aims The beneficial effects of probiotic consumption on age-related decline in
cerebral function have been previously reported in the literature; however, the mechanistic …
cerebral function have been previously reported in the literature; however, the mechanistic …
Long-term neuroinflammation induced by influenza A virus infection and the impact on hippocampal neuron morphology and function
Acute influenza infection has been reported to be associated with neurological symptoms.
However, the long-term consequences of an infection with neurotropic and non-neurotropic …
However, the long-term consequences of an infection with neurotropic and non-neurotropic …
Prolonged exposure to lung-derived cytokines is associated with activation of microglia in patients with COVID-19
BACKGROUND Survivors of pneumonia, including SARS-CoV-2 pneumonia, are at
increased risk for cognitive dysfunction and dementia. In rodent models, cognitive …
increased risk for cognitive dysfunction and dementia. In rodent models, cognitive …
Kaempferol acts through mitogen‐activated protein kinases and protein kinase B/AKT to elicit protection in a model of neuroinflammation in BV2 microglial cells
SE Park, K Sapkota, S Kim, H Kim… - British journal of …, 2011 - Wiley Online Library
BACKGROUND AND PURPOSE Kaempferol, a dietary flavonoid and phyto‐oestrogen, is
known to have anti‐inflammatory properties. Microglial activation has been implicated in …
known to have anti‐inflammatory properties. Microglial activation has been implicated in …
(−)‐Epigallocatechin gallate inhibits lipopolysaccharide‐induced microglial activation and protects against inflammation‐mediated dopaminergic neuronal injury
R Li, YG Huang, D Fang, WD Le - Journal of neuroscience …, 2004 - Wiley Online Library
Microglial activation is believed to play a pivotal role in the selective neuronal injury
associated with several neurodegenerative disorders, including Parkinson's disease (PD) …
associated with several neurodegenerative disorders, including Parkinson's disease (PD) …
[HTML][HTML] How dietary advanced glycation end products could facilitate the occurrence of food allergy
L Paparo, S Coppola, R Nocerino, L Pisapia… - Journal of Allergy and …, 2024 - Elsevier
Background Food allergy (FA) is one of the most common chronic conditions in children with
an increasing prevalence facilitated by the exposure to environmental factors in predisposed …
an increasing prevalence facilitated by the exposure to environmental factors in predisposed …
Metabotropic glutamate receptor 5 activation inhibits microglial associated inflammation and neurotoxicity
The Group I metabotropic glutamate receptor 5 (mGluR5) can modulate addiction, pain, and
neuronal cell death. Expression of some mGluRs, such as Group II and III mGluRs, has been …
neuronal cell death. Expression of some mGluRs, such as Group II and III mGluRs, has been …