The biological applications of DNA nanomaterials: current challenges and future directions

W Ma, Y Zhan, Y Zhang, C Mao, X **e… - Signal transduction and …, 2021 - nature.com
DNA, a genetic material, has been employed in different scientific directions for various
biological applications as driven by DNA nanotechnology in the past decades, including …

In vitro selection of aptamers and their applications

MC DeRosa, A Lin, P Mallikaratchy… - Nature Reviews …, 2023 - nature.com
The introduction of the in vitro evolution method known as SELEX (systematic evolution of
ligands by exponential enrichment) more than 30 years ago led to the conception of …

Recent progress in aptamer discoveries and modifications for therapeutic applications

S Ni, Z Zhuo, Y Pan, Y Yu, F Li, J Liu… - … Applied Materials & …, 2020 - ACS Publications
Aptamers are oligonucleotide sequences with a length of about 25–80 bases which have
abilities to bind to specific target molecules that rival those of monoclonal antibodies. They …

Recent advances in polymeric drug delivery systems

YK Sung, SW Kim - Biomaterials Research, 2020 - spj.science.org
Background Polymeric drug delivery systems have been achieved great development in the
last two decades. Polymeric drug delivery has defined as a formulation or a device that …

Aptamers as targeted therapeutics: current potential and challenges

J Zhou, J Rossi - Nature reviews Drug discovery, 2017 - nature.com
Nucleic acid aptamers, often termed'chemical antibodies', are functionally comparable to
traditional antibodies, but offer several advantages, including their relatively small physical …

DNA origami: scaffolds for creating higher order structures

F Hong, F Zhang, Y Liu, H Yan - Chemical reviews, 2017 - ACS Publications
DNA has become one of the most extensively used molecular building blocks for
engineering self-assembling materials. DNA origami is a technique that uses hundreds of …

Degradable controlled-release polymers and polymeric nanoparticles: mechanisms of controlling drug release

N Kamaly, B Yameen, J Wu, OC Farokhzad - Chemical reviews, 2016 - ACS Publications
The development of biodegradable polymers represents a revolution in medicine spanning
over 50 years and leading to significant biotechnological advancements in drug delivery …

Fluorescent chemical probes for accurate tumor diagnosis and targeting therapy

M Gao, F Yu, C Lv, J Choo, L Chen - Chemical Society Reviews, 2017 - pubs.rsc.org
Surgical resection of solid tumors is currently the gold standard and preferred therapeutic
strategy for cancer. Chemotherapy drugs also make a significant contribution by inhibiting …

Targeted doxorubicin-loaded mesenchymal stem cells-derived exosomes as a versatile platform for fighting against colorectal cancer

E Bagheri, K Abnous, SA Farzad, SM Taghdisi… - Life sciences, 2020 - Elsevier
Exosomes hold great potential for cancer treatment to deliver therapeutics due to its inherent
low immunogenicity. Exosomes are biocompatible cell-exocytosed secreted vesicles by …

Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology

N Bertrand, J Wu, X Xu, N Kamaly… - Advanced drug delivery …, 2014 - Elsevier
Cancer nanotherapeutics are progressing at a steady rate; research and development in the
field has experienced an exponential growth since early 2000's. The path to the …