Rho‐kinase/ROCK: a key regulator of the cytoskeleton and cell polarity
M Amano, M Nakayama, K Kaibuchi - Cytoskeleton, 2010 - Wiley Online Library
Rho‐associated kinase (Rho‐kinase/ROCK/ROK) is an effector of the small GTPase Rho
and belongs to the AGC family of kinases. Rho‐kinase has pleiotropic functions including …
and belongs to the AGC family of kinases. Rho‐kinase has pleiotropic functions including …
Rho-associated coiled-coil containing kinases (ROCK) structure, regulation, and functions
Rho-associated coiled-coil containing kinases (ROCK) were originally identified as effectors
of the RhoA small GTPase.–They belong to the AGC family of serine/threonine kinases and …
of the RhoA small GTPase.–They belong to the AGC family of serine/threonine kinases and …
Polo-like kinase 1 (PLK1) signaling in cancer and beyond
S Iliaki, R Beyaert, IS Afonina - Biochemical pharmacology, 2021 - Elsevier
PLK1 is an evolutionary conserved Ser/Thr kinase that is best known for its role in cell cycle
regulation and is expressed predominantly during the G2/S and M phase of the cell cycle …
regulation and is expressed predominantly during the G2/S and M phase of the cell cycle …
Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy
K Strebhardt - Nature reviews Drug discovery, 2010 - nature.com
The polo-like kinase 1 (PLK1) acts in concert with cyclin-dependent kinase 1–cyclin B1 and
Aurora kinases to orchestrate a wide range of critical cell cycle events. Because PLK1 has …
Aurora kinases to orchestrate a wide range of critical cell cycle events. Because PLK1 has …
Shared and separate functions of polo-like kinases and aurora kinases in cancer
S Lens, EE Voest, RH Medema - Nature Reviews Cancer, 2010 - nature.com
Large numbers of inhibitors for polo-like kinases and aurora kinases are currently being
evaluated as anticancer drugs. Interest in these drugs is fuelled by the idea that these …
evaluated as anticancer drugs. Interest in these drugs is fuelled by the idea that these …
Present and future perspective on PLK1 inhibition in cancer treatment
Polo-like kinase 1 (PLK1) is the principle member of the well conserved serine/threonine
kinase family. PLK1 has a key role in the progression of mitosis and recent evidence …
kinase family. PLK1 has a key role in the progression of mitosis and recent evidence …
The function of Rho-associated kinases ROCK1 and ROCK2 in the pathogenesis of cardiovascular disease
S Hartmann, AJ Ridley, S Lutz - Frontiers in pharmacology, 2015 - frontiersin.org
Rho-associated kinases ROCK1 and ROCK2 are serine/threonine kinases that are
downstream targets of the small GTPases RhoA, RhoB, and RhoC. ROCKs are involved in …
downstream targets of the small GTPases RhoA, RhoB, and RhoC. ROCKs are involved in …
Polo-like kinases: conservation and divergence in their functions and regulation
Polo-like kinases (Plks) are potent regulators of M phase that are conserved from yeasts to
humans. Their roles in mitotic entry, spindle pole functions and cytokinesis are broadly …
humans. Their roles in mitotic entry, spindle pole functions and cytokinesis are broadly …
The same, only different–DNA damage checkpoints and their reversal throughout the cell cycle
Cell cycle checkpoints activated by DNA double-strand breaks (DSBs) are essential for the
maintenance of the genomic integrity of proliferating cells. Following DNA damage, cells …
maintenance of the genomic integrity of proliferating cells. Following DNA damage, cells …
The decision to enter mitosis: feedback and redundancy in the mitotic entry network
The decision to enter mitosis is mediated by a network of proteins that regulate activation of
the cyclin B–Cdk1 complex. Within this network, several positive feedback loops can amplify …
the cyclin B–Cdk1 complex. Within this network, several positive feedback loops can amplify …