Artificial intelligence velocimetry and microaneurysm-on-a-chip for three-dimensional analysis of blood flow in physiology and disease

S Cai, H Li, F Zheng, F Kong, M Dao… - Proceedings of the …, 2021 - National Acad Sciences
Understanding the mechanics of blood flow is necessary for develo** insights into
mechanisms of physiology and vascular diseases in microcirculation. Given the limitations of …

Integrating blood cell mechanics, platelet adhesive dynamics and coagulation cascade for modelling thrombus formation in normal and diabetic blood

A Yazdani, Y Deng, H Li, E Javadi… - Journal of the …, 2021 - royalsocietypublishing.org
Normal haemostasis is an important physiological mechanism that prevents excessive
bleeding during trauma, whereas the pathological thrombosis especially in diabetics leads …

Blood viscosity in subjects with type 2 diabetes mellitus: roles of hyperglycemia and elevated plasma fibrinogen

J Sun, K Han, M Xu, L Li, J Qian, L Li, X Li - Frontiers in Physiology, 2022 - frontiersin.org
The viscosity of blood is an indicator in the understanding and treatment of disease. An
elevated blood viscosity has been demonstrated in patients with Type 2 Diabetes Mellitus …

Computational investigation of blood cell transport in retinal microaneurysms

H Li, Y Deng, K Sampani, S Cai, Z Li… - PLoS Computational …, 2022 - journals.plos.org
Microaneurysms (MAs) are one of the earliest clinically visible signs of diabetic retinopathy
(DR). MA leakage or rupture may precipitate local pathology in the surrounding neural retina …

Computational modeling of blood component transport related to coronary artery thrombosis in Kawasaki disease

N Grande Gutiérrez, M Alber, AM Kahn… - PLoS computational …, 2021 - journals.plos.org
Coronary artery thrombosis is the major risk associated with Kawasaki disease (KD). Long-
term management of KD patients with persistent aneurysms requires a thrombotic risk …

Hematological and Hemorheological Parameters of Blood Platelets as Biomarkers in Diabetes Mellitus Type 2: A Comprehensive Review

E Zvetkova, I Ivanov, E Koytchev, N Antonova… - Applied Sciences, 2024 - mdpi.com
Diabetes mellitus type 2 (DM2) is a hypercoagulable state with enhanced platelet (PLT)
activation and increased clo ing factor production. Simultaneously, the fibrinolytic cell system …

Coagulo-Net: Enhancing the mathematical modeling of blood coagulation using physics-informed neural networks

Y Qian, G Zhu, Z Zhang, S Modepalli, Y Zheng… - Neural Networks, 2024 - Elsevier
Blood coagulation, which involves a group of complex biochemical reactions, is a crucial
step in hemostasis to stop bleeding at the injury site of a blood vessel. Coagulation …

Recent advances in computational modeling of biomechanics and biorheology of red blood cells in diabetes

YX Deng, HY Chang, H Li - Biomimetics, 2022 - mdpi.com
Diabetes mellitus, a metabolic disease characterized by chronically elevated blood glucose
levels, affects about 29 million Americans and more than 422 million adults all over the …

A multiscale model for shear-mediated platelet adhesion dynamics: correlating in silico with in vitro results

P Wang, J Sheriff, P Zhang, Y Deng… - Annals of Biomedical …, 2023 - Springer
Platelet adhesion to blood vessel walls is a key initial event in thrombus formation in both
vascular disease processes and prosthetic cardiovascular devices. We extended a …

Multiphase continuum modeling of thrombosis in aneurysms and recirculation zones

A Bouchnita, AV Belyaev, V Volpert - Physics of Fluids, 2021 - pubs.aip.org
Aneurysms of saccular shape are usually associated with a slow, almost stagnant blood
flow, as well as a consequent emergence of blood clots. Despite the practical importance …