Escherichia coli is considered to be the best-known microorganism given the large number
of published studies detailing its genes, its genome and the biochemical functions of its …

The sustainable production of solvents from above ground carbon is highly desired. Several
clostridia naturally produce solvents and use a variety of renewable and waste-derived …

Highlights•Reaction directionalities versus enzyme reversibility: role of thermodynamics.•
Assessment of methods for thermodynamics-based analysis of metabolic …

Microbial cell factories (MCFs) are of considerable interest to convert low value renewable
substrates to biofuels and high value chemicals. This review highlights the progress of …

The CRISPR-Cas system has enabled the development of sophisticated, multigene
metabolic engineering programs through the use of guide RNA-directed activation or …

Lichen associations, a classic model for successful and sustainable interactions between
micro-organisms, have been studied for many years. However, there are significant gaps in …

Abstract 2016, was the 100 years anniversary from launching of the first industrial acetone-
butanol-ethanol (ABE) microbial production process. Despite this long period and also …

Engineering industrial microorganisms for ambitious applications, for example, the
production of second-generation biofuels such as butanol, is impeded by a lack of …

Metabolic pathways can be engineered to maximize the synthesis of various products of
interest. With the advent of computational systems biology, this endeavour is usually carried …

Metabolic modelling has entered a mature phase with dozens of methods and software
implementations available to the practitioner and the theoretician. It is not easy for a …