A simple yet multifaceted 90 years old, evergreen enzyme: Carbonic anhydrase, its inhibition and activation
Advances in the carbonic anhydrase (CA, EC 4.2. 1.1) research over the last three decades
are presented, with an emphasis on the deciphering of the activation mechanism, the …
are presented, with an emphasis on the deciphering of the activation mechanism, the …
Comprehensive insights on environmental adaptation strategies in Antarctic bacteria and biotechnological applications of cold adapted molecules
Climate change and the induced environmental disturbances is one of the major threats that
have a strong impact on bacterial communities in the Antarctic environment. To cope with …
have a strong impact on bacterial communities in the Antarctic environment. To cope with …
Bacterial ι-carbonic anhydrase: a new active class of carbonic anhydrase identified in the genome of the Gram-negative bacterium Burkholderia territorii
The carbonic anhydrases (CAs, EC 4.2. 1.1) catalyse a simple but physiologically crucial
reversible reaction, the carbon dioxide hydration with the production of bicarbonate and …
reversible reaction, the carbon dioxide hydration with the production of bicarbonate and …
Enzymes from marine polar regions and their biotechnological applications
The microorganisms that evolved at low temperatures express cold-adapted enzymes
endowed with unique catalytic properties in comparison to their mesophilic homologues, ie …
endowed with unique catalytic properties in comparison to their mesophilic homologues, ie …
Development of Penicillin-Based Carbonic Anhydrase Inhibitors Targeting Multidrug-Resistant Neisseria gonorrhoeae
The development of antibacterial drugs with new mechanisms of action is crucial in
combating the rise of antibiotic-resistant infections. Bacterial carbonic anhydrases (CAs, EC …
combating the rise of antibiotic-resistant infections. Bacterial carbonic anhydrases (CAs, EC …
Boron-containing carbonic anhydrases inhibitors
Over the last decades, the medicinal chemistry of boron-based compounds has been
extensively explored, designing valuable small molecule drugs to tackle diseases and …
extensively explored, designing valuable small molecule drugs to tackle diseases and …
New light on bacterial carbonic anhydrases phylogeny based on the analysis of signal peptide sequences
Among protein families, carbonic anhydrases (CAs, EC 4.2. 1.1) are metalloenzymes
characterized by a common reaction mechanism in all life domains: the carbon dioxide …
characterized by a common reaction mechanism in all life domains: the carbon dioxide …
Synthesis, biological evaluation, and in silico studies of potential activators of apoptosis and carbonic anhydrase inhibitors on isatin-5-sulfonamide scaffold
Carbonic anhydrase IX is a promising target for the search for new antitumor compounds
with improved properties. Using the molecular hybridization approach, on the basis of …
with improved properties. Using the molecular hybridization approach, on the basis of …
Inhibition of α-, β-, γ-, δ-, ζ-and η-class carbonic anhydrases from bacteria, fungi, algae, diatoms and protozoans with famotidine
Famotidine, an antiulcer drug belonging to the H2 antagonists class of pharmacological
agents, was recently shown to potently inhibit human (h) and bacterial carbonic anhydrases …
agents, was recently shown to potently inhibit human (h) and bacterial carbonic anhydrases …
Design, synthesis, biological evaluation and docking analysis of pyrrolidine-benzenesulfonamides as carbonic anhydrase or acetylcholinesterase inhibitors and …
The synthesis and biological assessment of novel multi-functionalized pyrrolidine-containing
benzenesulfonamides were reported along with their antimicrobial, antifungal, CAs …
benzenesulfonamides were reported along with their antimicrobial, antifungal, CAs …