Pathophysiology of RAGE in inflammatory diseases

H Dong, Y Zhang, Y Huang, H Deng - Frontiers in Immunology, 2022 - frontiersin.org
The receptor for advanced glycation end products (RAGE) is a non-specific multi-ligand
pattern recognition receptor capable of binding to a range of structurally diverse ligands …

Revisiting excitotoxicity in traumatic brain injury: from bench to bedside

D Baracaldo-Santamaría, DF Ariza-Salamanca… - Pharmaceutics, 2022 - mdpi.com
Traumatic brain injury (TBI) is one of the leading causes of morbidity and mortality.
Consequences vary from mild cognitive impairment to death and, no matter the severity of …

AGE-RAGE synergy influences programmed cell death signaling to promote cancer

BN Waghela, FU Vaidya, K Ranjan, AS Chhipa… - Molecular and Cellular …, 2021 - Springer
Advanced glycation end products (AGEs) are formed as a result of non-enzymatic reaction
between the free reducing sugars and proteins, lipids, or nucleic acids. AGEs are …

Focal Adhesion Kinase (FAK)-Hippo/YAP transduction signaling mediates the stimulatory effects exerted by S100A8/A9-RAGE system in triple-negative breast cancer …

DC Rigiracciolo, N Nohata, R Lappano, F Cirillo… - Journal of Experimental …, 2022 - Springer
Background Understanding the intricate signaling network involved in triple-negative breast
cancer (TNBC) represents a challenge for develo** novel therapeutic approaches. Here …

[HTML][HTML] Atherosclerosis, diabetes mellitus, and cancer: common epidemiology, shared mechanisms, and future management

V Katsi, I Papakonstantinou, K Tsioufis - International Journal of …, 2023 - mdpi.com
The involvement of cardiovascular disease in cancer onset and development represents a
contemporary interest in basic science. It has been recognized, from the most recent …

Echinacoside-zinc nanomaterial inhibits skin glycation by suppressing the transcriptional activation of the receptor for advanced glycation end-products

J Han, Y Sun, T Wu, X Hou, S Zheng, H Zhang, T Lin… - ACS …, 2023 - ACS Publications
Glycation is a nonenzymatically catalyzed spontaneous reaction that eventually leads to the
formation of advanced glycation end-products (AGEs), which can bind to the receptor for …

AGEs and RAGE: Metabolic and molecular signatures of the glycation-inflammation axis in malignant or metastatic cancers

G Palanissami, SFD Paul - Exploration of Targeted Anti-tumor …, 2023 - pmc.ncbi.nlm.nih.gov
From attributing mutations to cancers with the advent of cutting-edge genetic technology in
recent decades, to re-searching the age-old theory of intrinsic metabolic shift of cancers …

RAGE and its ligands: from pathogenesis to therapeutics

N Jangde, R Ray, V Rai - Critical reviews in biochemistry and …, 2020 - Taylor & Francis
Receptor for advanced glycation end products (RAGE) is an immunoglobulin-like receptor
present on cell surface. RAGE binds to an array of structurally diverse ligands, acts as a …

Cancer-associated fibroblasts in the breast tumor microenvironment

MB Giorello, FR Borzone, V Labovsky… - Journal of Mammary …, 2021 - Springer
Years of investigation have shed light on a theory in which breast tumor epithelial cells are
under the effect of the stromal microenvironment. This review aims to discuss recent findings …

[HTML][HTML] Advanced Glycation End-Products Acting as Immunomodulators for Chronic Inflammation, Inflammaging and Carcinogenesis in Patients with Diabetes and …

CY Shen, CH Lu, CF Cheng, KJ Li, YM Kuo, CH Wu… - Biomedicines, 2024 - mdpi.com
Increased production of advanced glycation end products (AGEs) among reducing sugars
(glucose, fructose, galactose, or ribose) and amino acids/proteins via non-enzymatic …