In order to ensure normal body function, the human body is dependent on a tight control of
its blood glucose levels. This is accomplished by a highly sophisticated network of various …

Human neuropeptide Y (hNPY) is one of the most widely expressed neurotransmitters in the
human central and peripheral nervous systems. It consists of 36 highly conserved amino …

Abstract Activation of Agouti-Related Peptide (AgRP)-expressing neurons promotes feeding
and insulin resistance. Here, we examine the contribution of neuropeptide Y (NPY) …

NeuroD, a transactivator of the insulin gene, is critical for development of the endocrine
pancreas, and NeuroD mutations cause MODY6 in humans. To investigate the role of …

Obesity is a global epidemic and a major predisposing factor for cancer. Increasing
evidence shows that obesity-associated stress is a key driver of cancer risk and progression …

Aims/hypothesis Chronic inflammation in type 2 diabetes is proposed to affect islets as well
as insulin target organs. However, the nature of islet inflammation and its effects on islet …

Precise regulation of circulating glucose is crucial for human health and ensures a sufficient
supply to the brain, which relies almost exclusively on glucose for metabolic energy …

The relentless nature and increasing prevalence of human pancreatic diseases, in
particular, diabetes mellitus and adenocarcinoma, has motivated further understanding of …

Neuropeptide Y (NPY) is best known for its effects in the brain as an orexigenic and
anxiolytic agent and in reducing energy expenditure. NPY is also co-expressed with …

The regulation of the secretory function of the pancreas by numerous hormones suggests
that there are multiple and perhaps redundant signals governing the control of this important …