Bioconjugation methodologies have proven to play a central enabling role in the recent
development of biotherapeutics and chemical biology approaches. Recent endeavours in …

Cys‐tematic modification: Cysteine is a versatile amino acid for selective chemical
modification of proteins. Both chemical and biological innovations made possible by …

1.1 Aims This review updates our original review on the synthesis of glycoproteins.(1) Its
aims, therefore, are 2-fold: to highlight, first, key developments since 2002 and, second …

Bioconjugates represent an emerging class of medicines, which offer therapeutic
opportunities overtaking those of the individual components. Many novel bioconjugates …

Glycosylation is among the most common post-translational modifications that proteins
undergo that may affect many of their activities. It may also modify the underlying energy …

The inefficient translocation of proteins across biological membranes limits their application
as potential therapeutics and research tools. In many cases, the translocation of a protein …

Cyclometalated gold( iii ) complexes for chemoselective cysteine modification via ligand
controlled C–S bond-forming reductive elimination - Chemical Communications (RSC …

Glycosylation is often cited as having a stabilizing effect upon proteins with respect to
proteolysis, thermolysis and other forms of degradation. We present here a model study on …

Laccases are highly stable, industrially important enzymes capable of oxidizing a large
range of substrates. Causes for their stability are, as for other proteins, poorly understood. In …

Hydride transfer catalyzed by dihydrofolate reductase (DHFR) has been described
previously within an environmentally coupled model of hydrogen tunneling, where protein …