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Inflammation and immunity in the pathogenesis of pulmonary arterial hypertension
This review summarizes an expanding body of knowledge indicating that failure to resolve
inflammation and altered immune processes underlie the development of pulmonary arterial …
inflammation and altered immune processes underlie the development of pulmonary arterial …
Genetics and genomics of pulmonary arterial hypertension
Major discoveries have been obtained within the last decade in the field of hereditary
predisposition to pulmonary arterial hypertension (PAH). Among them, the identification of …
predisposition to pulmonary arterial hypertension (PAH). Among them, the identification of …
Immune and inflammatory cell involvement in the pathology of idiopathic pulmonary arterial hypertension
Rationale: Pulmonary arterial hypertension (PAH) is characterized by vasoconstriction and
vascular remodeling. Recent studies have revealed that immune and inflammatory …
vascular remodeling. Recent studies have revealed that immune and inflammatory …
Inflammation in pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) is characterized by pulmonary vascular remodeling
of the precapillary pulmonary arteries, with excessive proliferation of vascular cells. Although …
of the precapillary pulmonary arteries, with excessive proliferation of vascular cells. Although …
Interleukin-6 overexpression induces pulmonary hypertension
Inflammatory cytokine interleukin (IL)-6 is elevated in the serum and lungs of patients with
pulmonary artery hypertension (PAH). Several animal models of PAH cite the potential role …
pulmonary artery hypertension (PAH). Several animal models of PAH cite the potential role …
Inflammation, growth factors, and pulmonary vascular remodeling
Inflammatory processes are prominent in various types of human and experimental
pulmonary hypertension (PH) and are increasingly recognized as major pathogenic …
pulmonary hypertension (PH) and are increasingly recognized as major pathogenic …
Molecular pathogenesis of pulmonary arterial hypertension
Recent clinical and experimental studies are redefining the cellular and molecular bases of
pulmonary arterial hypertension (PAH). The genetic abnormalities first identified in …
pulmonary arterial hypertension (PAH). The genetic abnormalities first identified in …
Interleukin-6/interleukin-21 signaling axis is critical in the pathogenesis of pulmonary arterial hypertension
T Hashimoto-Kataoka, N Hosen, T Sonobe… - Proceedings of the …, 2015 - pnas.org
IL-6 is a multifunctional proinflammatory cytokine that is elevated in the serum of patients
with pulmonary arterial hypertension (PAH) and can predict the survival of patients with …
with pulmonary arterial hypertension (PAH) and can predict the survival of patients with …
The role of vasculature and angiogenesis in respiratory diseases
In European countries, nearly 10% of all hospital admissions are related to respiratory
diseases, mainly chronic life-threatening diseases such as COPD, pulmonary hypertension …
diseases, mainly chronic life-threatening diseases such as COPD, pulmonary hypertension …
Mechanisms of pulmonary vascular dysfunction in pulmonary hypertension and implications for novel therapies
Pulmonary hypertension (PH) is a serious disease characterized by various degrees of
pulmonary vasoconstriction and progressive fibroproliferative remodeling and inflammation …
pulmonary vasoconstriction and progressive fibroproliferative remodeling and inflammation …