[HTML][HTML] Obesity and female infertility: potential mediators of obesity's impact
DE Broughton, KH Moley - Fertility and sterility, 2017 - Elsevier
The worldwide upward trend in obesity has been dramatic, now affecting more than 20% of
American women of reproductive age. Obesity is associated with many adverse maternal …
American women of reproductive age. Obesity is associated with many adverse maternal …
Metabolic co-dependence of the oocyte and cumulus cells: essential role in determining oocyte developmental competence
BACKGROUND Within the antral follicle, the oocyte is reliant on metabolic support from its
surrounding somatic cells. Metabolism plays a critical role in oocyte developmental …
surrounding somatic cells. Metabolism plays a critical role in oocyte developmental …
[HTML][HTML] Oocyte environment: follicular fluid and cumulus cells are critical for oocyte health
Bidirectional somatic cell–oocyte signaling is essential to create a changing intrafollicular
microenvironment that controls primordial follicle growth into a cohort of growing follicles …
microenvironment that controls primordial follicle growth into a cohort of growing follicles …
Obesity induces ovarian inflammation and reduces oocyte quality
In the United States, 36.5% of women between the ages of 20 and 39 years are obese. This
obesity results in not only metabolic disorders including type II diabetes and cardiovascular …
obesity results in not only metabolic disorders including type II diabetes and cardiovascular …
Lipids and oocyte developmental competence: the role of fatty acids and β-oxidation
Metabolism and ATP levels within the oocyte and adjacent cumulus cells are associated
with quality of oocyte and optimal development of a healthy embryo. Lipid metabolism …
with quality of oocyte and optimal development of a healthy embryo. Lipid metabolism …
Influence of follicular fluid and cumulus cells on oocyte quality: clinical implications
An equilibrium needs to be established by the cellular and acellular components of the
ovarian follicle if developmental competence is to be acquired by the oocyte. Both cumulus …
ovarian follicle if developmental competence is to be acquired by the oocyte. Both cumulus …
Parenting from before conception
At fertilization, the gametes endow the embryo with a genomic blueprint, the integrity of
which is affected by the age and environmental exposures of both parents. Recent studies …
which is affected by the age and environmental exposures of both parents. Recent studies …
High fat diet induced developmental defects in the mouse: oocyte meiotic aneuploidy and fetal growth retardation/brain defects
KM Luzzo, Q Wang, SH Purcell, M Chi, PT Jimenez… - PloS one, 2012 - journals.plos.org
Background Maternal obesity is associated with poor outcomes across the reproductive
spectrum including infertility, increased time to pregnancy, early pregnancy loss, fetal loss …
spectrum including infertility, increased time to pregnancy, early pregnancy loss, fetal loss …
Human female meiosis revised: new insights into the mechanisms of chromosome segregation and aneuploidies from advanced genomics and time-lapse imaging
A Capalbo, ER Hoffmann, D Cimadomo… - Human reproduction …, 2017 - academic.oup.com
ABSTRACT BACKGROUND The unbalanced transmission of chromosomes in human
gametes and early preimplantation embryos causes aneuploidy, which is a major cause of …
gametes and early preimplantation embryos causes aneuploidy, which is a major cause of …
[PDF][PDF] Mitochondria and lipid metabolism in mammalian oocytes and early embryos
J Bradley, K Swann - International Journal of Developmental Biology, 2019 - core.ac.uk
Mammalian oocytes and early cleavage-stage embryos are critically dependent on their~
100,000 mitochondria to develop from ovulation to compacted morula stage. They rely …
100,000 mitochondria to develop from ovulation to compacted morula stage. They rely …