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MMP-2 and its implications on cardiac function and structure: interplay with inflammation in hypertension
Hypertension is one of the leading risk factors for the development of heart failure. Despite
being a multifactorial disease, in recent years, preclinical and clinical studies suggest strong …
being a multifactorial disease, in recent years, preclinical and clinical studies suggest strong …
Differential roles of eosinophils in cardiovascular disease
Eosinophils are essential innate immune cells in allergic responses. Accumulating evidence
indicates that eosinophils also participate in the pathogenesis of cardiovascular diseases …
indicates that eosinophils also participate in the pathogenesis of cardiovascular diseases …
Cationic proteins from eosinophils bind bone morphogenetic protein receptors promoting vascular calcification and atherogenesis
Aims Blood eosinophil count and eosinophil cationic protein (ECP) concentration are risk
factors of cardiovascular diseases. This study tested whether and how eosinophils and ECP …
factors of cardiovascular diseases. This study tested whether and how eosinophils and ECP …
SerpinB1 targeting safeguards against pathological cardiac hypertrophy and remodelling by suppressing cardiomyocyte pyroptosis and inflammation initiation
C Lan, G Fang, X Li, X Chen, Y Chen… - Cardiovascular …, 2024 - academic.oup.com
Aims While the pivotal role of inflammation in pathological cardiac hypertrophy and
remodelling is widely acknowledged, the mechanisms triggering inflammation initiation …
remodelling is widely acknowledged, the mechanisms triggering inflammation initiation …
[HTML][HTML] Advances in understanding of the role of immune cell phenotypes in hypertension and associated vascular disease
Many studies in the last 20 years have identified a contribution of inflammation and immune
mechanisms to the pathophysiology of hypertension. Innate and adaptive immunity …
mechanisms to the pathophysiology of hypertension. Innate and adaptive immunity …
Interstitial eosinophilic aggregates and kidney outcome in patients with CKD
Background Interstitial eosinophilic aggregates are observed in various kidney diseases, but
their clinical implications remain unknown. We assessed the association between interstitial …
their clinical implications remain unknown. We assessed the association between interstitial …
Association between blood eosinophil levels and prognosis in critically ill patients with different heart failure phenotypes
C Guan, K Wang, A Gong, Y Zhao, H Yu, S Zhang… - Scientific Reports, 2025 - nature.com
Heart failure (HF) is associated with poor prognosis. While various immune markers have
been linked to HF outcomes, the relationship between eosinophils (EOS) and prognosis …
been linked to HF outcomes, the relationship between eosinophils (EOS) and prognosis …
Changes in Blood Eosinophil Counts Predict the Death of Patients With Myocardial Infarction After Hospital Discharge
Background Preclinical studies demonstrate a cardioprotective role of eosinophils in acute
myocardial infarction. Yet clinical studies show conflicting correlations between blood …
myocardial infarction. Yet clinical studies show conflicting correlations between blood …
The immunoregulatory potential of eosinophil subsets
Eosinophils have traditionally been viewed as pathological effector cells primarily involved
in antiparasitic and allergic immune reactions; however, it is becoming increasingly …
in antiparasitic and allergic immune reactions; however, it is becoming increasingly …
Association between fibrosis‐4 index and cognitive impairment in elderly patients with hypertension: A cross‐sectional study
H Ding, J Wang, S Liu, Y ** hepatic fibrosis. The aim of the study was to explore …