Cancer is a dynamic disease. During the course of disease, cancers generally become more
heterogeneous. As a result of this heterogeneity, the bulk tumour might include a diverse …

The cancer stem cell (CSC) concept was proposed four decades ago, and states that tumor
growth, analogous to the renewal of healthy tissues, is fueled by small numbers of dedicated …

The success of anticancer therapy is usually limited by the development of drug resistance.
Such acquired resistance is driven, in part, by intratumoural heterogeneity—that is, the …

Metastasis causes most cancer deaths, yet this process remains one of the most enigmatic
aspects of the disease. Building on new mechanistic insights emerging from recent …

Genetic analyses have shaped much of our understanding of cancer. However, it is
becoming increasingly clear that cancer cells display features of normal tissue organization …

Cancer stem cells (CSCs) have important roles in tumour development, relapse and
metastasis; the intrinsic self-renewal characteristics and tumorigenic properties of these cells …

Increased generation of reactive oxygen species (ROS) and an altered redox status have
long been observed in cancer cells, and recent studies suggest that this biochemical …

Cancer stem cells (CSCs) are tumor cells that have the principal properties of self-renewal,
clonal tumor initiation capacity, and clonal long-term repopulation potential. CSCs reside in …

Tumors are cellularly and molecularly heterogeneous, with subsets of undifferentiated
cancer cells exhibiting stem cell-like features (CSCs). Epithelial to mesenchymal transitions …

Transitions between epithelial and mesenchymal states have crucial roles in embryonic
development. Emerging data suggest a role for these processes in regulating cellular …