Emerging evidence indicates that impaired cellular energy metabolism is the defining
characteristic of nearly all cancers regardless of cellular or tissue origin. In contrast to normal …

Diet-related factors are thought to account for about 30% of cancers in developed countries.
Obesity increases the risk of cancers in the oesophagus, colorectum, breast, endometrium …

Resveratrol, a naturally occurring polyphenol, has cancer chemopreventive properties in
preclinical models. It has been shown to downregulate the levels of insulin-like growth factor …

Dietary restriction has been shown to have several health benefits including increased
insulin sensitivity, stress resistance, reduced morbidity, and increased life span. The …

Calorie restriction (CR) and alternate-day fasting (ADF) represent 2 different forms of dietary
restriction. Although the effects of CR on chronic disease prevention were reviewed …

Calorie restriction (CR) is the most effective and reproducible intervention for increasing
lifespan in a variety of animal species, including mammals. CR is also the most potent …

Secular changes and worldwide variations in incidence rates of colorectal cancer, along
with results from twin and migrant studies, provide compelling evidence that environmental …

Background Glioma, including anaplastic astrocytoma and glioblastoma multiforme (GBM)
are among the most commonly diagnosed malignant adult brain tumors. GBM is a highly …

Brain tumours lack metabolic versatility and are dependent largely on glucose for energy.
This contrasts with normal brain tissue that can derive energy from both glucose and ketone …

Experimental, epidemiological and clinical evidence implicates insulin resistance and its
accompanying hyperinsulinaemia in the development of cancer, but the relative importance …