Patient-derived xenograft (PDX) models, in which tumor tissues from patients are implanted
into immunocompromised or humanized mice, have shown superiority in recapitulating the …

Colorectal cancer (CRC) is the third most common diagnosed malignancy among both
sexes in the United States as well as in the European Union. While the incidence and …

Cancer-associated fibroblasts (CAFs) are highly heterogeneous. With the lack of a
comprehensive understanding of CAFs' functional distinctions, it remains unclear how …

Sarcomas are complex mesenchymal neoplasms with a poor prognosis. Their clinical
management is highly challenging due to their heterogeneity and insensitivity to current …

Simple Summary The patient-derived xenograft (PDX) model is the in vivo standard for
cancer research as a preclinical platform. Besides its merits, we describe the general …

Patient‐derived xenograft (PDX) models are widely used as preclinical cancer models and
are considered better than cell culture models in recapitulating the histological features …

Fibroblast activation protein (FAP), a fundamental component of the tumor stroma, is
overexpressed in cancer-associated fibroblasts (CAFs). As a promising theranostic probe …

Patient‐derived tumor xenograft (PDX) models, a method involving the surgical extraction of
tumor tissues from cancer patients and subsequent transplantation into immunodeficient …

Highlights•PDXs are obtained by growing human tumours into immunocompromised
mice.•Expansion of tumours as PDXs provides unlimited material for molecular …

Colorectal cancer (CRC), despite the advances in screening and surveillance, remains the
second most common cause of cancer death worldwide. The biological inadequacy of pre …