Abstract Moorman, Antoon FM, and Vincent M. Christoffels. Cardiac Chamber Formation:
Development, Genes, and Evolution. Physiol Rev 83: 1223-1267, 2003; 10.1152/physrev …

The mammalian heart is crafted from a few progenitor cells that are subject to rapidly
changing sets of instructions from their environment and from within. These instructions …

The ability to direct the differentiation of human pluripotent stem cells (hPSCs) to the different
cardiomyocyte subtypes is a prerequisite for modeling specific forms of cardiovascular …

The sinoatrial node (SAN) is the primary pacemaker of the heart and controls heart rate
throughout life. Failure of SAN function due to congenital disease or aging results in slowing …

Advances in our understanding of cardiovascular development have provided a roadmap for
the directed differentiation of human pluripotent stem cells (hPSCs) to the major cell types …

Following gastrulation and establishment of the three embryonic germ layers, the first
definitive organ to form in the embryo is the heart, whose morphogenesis, growth, and …

Calcineurin signaling has been implicated in a broad spectrum of developmental processes
in a variety of organ systems. Calcineurin is a calmodulin-dependent, calcium-activated …

Establishment of anteroposterior (AP) polarity is one of the earliest decisions in
cardiogenesis and plays an important role in the coupling between heart and blood vessels …

Much of the heart, including the atria, right ventricle and outflow tract (OFT) is derived from a
progenitor cell population termed the second heart field (SHF) that contributes progressively …

Organogenesis requires the orchestrated development of multiple cell lineages that
converge, interact, and specialize to generate coherent functional structures, exemplified by …