Bace1 inhibitors for Alzheimer's disease: the past, present and any future?

FH Bazzari, AH Bazzari - Molecules, 2022 - mdpi.com
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder and the most
common cause of dementia in the elderly. The complexity of AD has hindered the …

New insights into butyrylcholinesterase: Pharmaceutical applications, selective inhibitors and multitarget-directed ligands

T Sun, T Zhen, CH Harakandi, L Wang, H Guo… - European Journal of …, 2024 - Elsevier
Butyrylcholinesterase (BChE), also known as pseudocholinesterase and serum
cholinesterase, is an isoenzyme of acetylcholinesterase (AChE). It mediates the degradation …

Role of protein phosphorylation in cell signaling, disease, and the intervention therapy

K Pang, W Wang, JX Qin, ZD Shi, L Hao, YY Ma… - MedComm, 2022 - Wiley Online Library
Protein phosphorylation is an important post‐transcriptional modification involving an
extremely wide range of intracellular signaling transduction pathways, making it an …

The role of glycogen synthase kinase 3 beta in neurodegenerative diseases

H Yu, M **ong, Z Zhang - Frontiers in Molecular Neuroscience, 2023 - frontiersin.org
Neurodegenerative diseases (NDDs) pose an increasingly prevalent threat to the well-being
and survival of elderly individuals worldwide. NDDs include Alzheimer's disease (AD) …

Targeting glycogen synthase kinase-3β for Alzheimer's disease: recent advances and future Prospects

Z Cheng, T Han, J Yao, K Wang, X Dong, F Yu… - European Journal of …, 2024 - Elsevier
Senile plaques induced by β-amyloid (Aβ) abnormal aggregation and neurofibrillary tangles
(NFT) caused by tau hyperphosphorylation are important pathological manifestations of …

[HTML][HTML] Qingxin Kaiqiao Fang decreases Tau hyperphosphorylation in Alzheimer's disease via the PI3K/Akt/GSK3β pathway in vitro and in vivo

S Liu, L Xu, Y Shen, L Wang, X Lai, H Hu - Journal of ethnopharmacology, 2024 - Elsevier
Ethnopharmacological relevance Alzheimer's disease (AD) belongs to the category of
“senile dementia” in traditional Chinese medicine. AD is associated with brain emptiness or …

Association Between Type 2 Diabetes Mellitus and Alzheimer's Disease: Common Molecular Mechanism and Therapeutic Targets

A Chauhan, S Dubey, S Jain - Cell Biochemistry and Function, 2024 - Wiley Online Library
Diabetes mellitus (DM) and Alzheimer's disease (AD) rates are rising, mirroring the global
trend of an aging population. Numerous epidemiological studies have shown that those with …

Impact of GSK-3β and CK-1δ on Wnt signaling pathway in alzheimer disease: A dual target approach

V Sharma, PC Sharma, V Yadav, RK Tonk, J Majeed… - Bioorganic …, 2024 - Elsevier
Alzheimer's disease (AD) is an enigmatic neurological illness that offers few treatment
options. Recent exploration has highlighted the crucial connection of the Wnt signaling …

Dendrobium nobile Lindl. alkaloid decreases Tau hyperphosphorylation via regulating PI3K/Akt/GSK-3β pathway in vitro and in vivo

J Huang, N Huang, Y Qiu, J Shi - Journal of ethnopharmacology, 2024 - Elsevier
Ethnopharmacological relevant Dendrobium is a traditional and precious Chinese medicinal
herb. The Compendium of Materia Medica describes its effects as “benefiting intelligence …

Natural compounds from herbs and nutraceuticals as glycogen synthase kinase‐3β inhibitors in Alzheimer's disease treatment

Z Zhao, Y Yuan, S Li, X Wang… - CNS Neuroscience & …, 2024 - Wiley Online Library
Background Alzheimer's disease (AD) pathogenesis is complex. The pathophysiology is not
fully understood, and safe and effective treatments are needed. Glycogen synthase kinase …