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Bace1 inhibitors for Alzheimer's disease: the past, present and any future?
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder and the most
common cause of dementia in the elderly. The complexity of AD has hindered the …
common cause of dementia in the elderly. The complexity of AD has hindered the …
New insights into butyrylcholinesterase: Pharmaceutical applications, selective inhibitors and multitarget-directed ligands
T Sun, T Zhen, CH Harakandi, L Wang, H Guo… - European Journal of …, 2024 - Elsevier
Butyrylcholinesterase (BChE), also known as pseudocholinesterase and serum
cholinesterase, is an isoenzyme of acetylcholinesterase (AChE). It mediates the degradation …
cholinesterase, is an isoenzyme of acetylcholinesterase (AChE). It mediates the degradation …
Role of protein phosphorylation in cell signaling, disease, and the intervention therapy
K Pang, W Wang, JX Qin, ZD Shi, L Hao, YY Ma… - MedComm, 2022 - Wiley Online Library
Protein phosphorylation is an important post‐transcriptional modification involving an
extremely wide range of intracellular signaling transduction pathways, making it an …
extremely wide range of intracellular signaling transduction pathways, making it an …
The role of glycogen synthase kinase 3 beta in neurodegenerative diseases
H Yu, M **ong, Z Zhang - Frontiers in Molecular Neuroscience, 2023 - frontiersin.org
Neurodegenerative diseases (NDDs) pose an increasingly prevalent threat to the well-being
and survival of elderly individuals worldwide. NDDs include Alzheimer's disease (AD) …
and survival of elderly individuals worldwide. NDDs include Alzheimer's disease (AD) …
Targeting glycogen synthase kinase-3β for Alzheimer's disease: recent advances and future Prospects
Z Cheng, T Han, J Yao, K Wang, X Dong, F Yu… - European Journal of …, 2024 - Elsevier
Senile plaques induced by β-amyloid (Aβ) abnormal aggregation and neurofibrillary tangles
(NFT) caused by tau hyperphosphorylation are important pathological manifestations of …
(NFT) caused by tau hyperphosphorylation are important pathological manifestations of …
[HTML][HTML] Qingxin Kaiqiao Fang decreases Tau hyperphosphorylation in Alzheimer's disease via the PI3K/Akt/GSK3β pathway in vitro and in vivo
S Liu, L Xu, Y Shen, L Wang, X Lai, H Hu - Journal of ethnopharmacology, 2024 - Elsevier
Ethnopharmacological relevance Alzheimer's disease (AD) belongs to the category of
“senile dementia” in traditional Chinese medicine. AD is associated with brain emptiness or …
“senile dementia” in traditional Chinese medicine. AD is associated with brain emptiness or …
Association Between Type 2 Diabetes Mellitus and Alzheimer's Disease: Common Molecular Mechanism and Therapeutic Targets
Diabetes mellitus (DM) and Alzheimer's disease (AD) rates are rising, mirroring the global
trend of an aging population. Numerous epidemiological studies have shown that those with …
trend of an aging population. Numerous epidemiological studies have shown that those with …
Impact of GSK-3β and CK-1δ on Wnt signaling pathway in alzheimer disease: A dual target approach
Alzheimer's disease (AD) is an enigmatic neurological illness that offers few treatment
options. Recent exploration has highlighted the crucial connection of the Wnt signaling …
options. Recent exploration has highlighted the crucial connection of the Wnt signaling …
Dendrobium nobile Lindl. alkaloid decreases Tau hyperphosphorylation via regulating PI3K/Akt/GSK-3β pathway in vitro and in vivo
J Huang, N Huang, Y Qiu, J Shi - Journal of ethnopharmacology, 2024 - Elsevier
Ethnopharmacological relevant Dendrobium is a traditional and precious Chinese medicinal
herb. The Compendium of Materia Medica describes its effects as “benefiting intelligence …
herb. The Compendium of Materia Medica describes its effects as “benefiting intelligence …
Natural compounds from herbs and nutraceuticals as glycogen synthase kinase‐3β inhibitors in Alzheimer's disease treatment
Z Zhao, Y Yuan, S Li, X Wang… - CNS Neuroscience & …, 2024 - Wiley Online Library
Background Alzheimer's disease (AD) pathogenesis is complex. The pathophysiology is not
fully understood, and safe and effective treatments are needed. Glycogen synthase kinase …
fully understood, and safe and effective treatments are needed. Glycogen synthase kinase …