Neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD),
and Huntington's disease (HD), are characterized by the progressive degeneration of …

If evolution was/is a fact, a simplified/unifying approach to explain cellular physiology is
warranted. Such a perspective should agree with the thermodynamic, kinetic, structural, and …

Mitochondrial ATP synthase plays a key role in inducing membrane curvature to establish
cristae. In Apicomplexa causing diseases such as malaria and toxoplasmosis, an unusual …

A family of apicomplexa-specific proteins containing AP2 DNA-binding domains (ApiAP2s)
was identified in malaria parasites. This family includes sequence-specific transcription …

Our current understanding of mitochondrial functioning is largely restricted to traditional
model organisms, which only represent a fraction of eukaryotic diversity. The unusual …

Bites of Anopheles mosquitoes transmit Plasmodium falciparum parasites that cause
malaria, which kills hundreds of thousands of people every year. Since the turn of this …

Drug resistance compromises control of malaria. Here, we show that resistance to a
commonly used antimalarial medication, atovaquone, is apparently unable to spread …

Gene drives hold promise for the genetic control of malaria vectors. The development of
vector population modification strategies hinges on the availability of effector mechanisms …

The mitochondrion of apicomplexan parasites is critical for parasite survival, although the full
complement of proteins that localize to this organelle has not been defined. Here we …

Cristae are infoldings of the mitochondrial inner membrane jutting into the organelle's
innermost compartment from narrow stems at their base called crista junctions. They are …