This chapter provides an overview of neurosteroids, especially their impact on the brain, sex
differences and their therapeutic potentials. Neurosteroids are synthesized within the brain …

Rationale Neurosteroids are steroids synthesized within the brain with rapid effects on
neuronal excitability. Allopregnanolone, allotetrahydrodeoxycorticosterone, and …

The epilepsies are common neurologic disorders characterized by spontaneous recurrent
seizures. Boys, girls, men, and women of all ages are affected by epilepsy and, in many …

This article describes the critical role of neurosteroids in postpartum depression (PPD) and
outlines the landmark pharmacological journey of brexanolone as a first-in-class …

Neurosteroids are key endogenous molecules in the brain that affect many neural functions.
We describe here recent advances in US National Institutes of Health (NIH)-sponsored and …

This article provides a succinct overview of sex differences in epilepsy and putative
molecular mechanisms underlying sex differences in seizure susceptibility in chemical …

There is a complex, bidirectional interdependence between sex steroid hormones and
epilepsy; hormones affect seizures, while seizures affect hormones thereby disturbing …

This article describes the recent advances in epileptogenesis and novel therapeutic
approaches for the prevention of epilepsy, with a special emphasis on the pharmacological …

When all of the epilepsies are considered, sex differences are not always clear, despite the
fact that many sex differences are known in the normal brain. Sex differences in epilepsy in …

A remarkable feature of the brain is its sexual dimorphism. Sexual dimorphism in brain
structure and function is associated with clinical implications documented previously in …